{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:49:09Z","timestamp":1773078549345,"version":"3.50.1"},"reference-count":8,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p> The aim of this study was to evaluate the effects of a traditional Chinese herbal medicine, Dai-kenchu-to (DKT), on obstructive bowel diseases in children. We have treated 46 pediatric patients with various obstructive bowel diseases with DKT: six patients with postoperative ileus, 12 with large abdominal surgery (including three neonates), one with ano-rectal anomaly, three with Hirschsprung's disease, two with functional bowel obstructions, one with SMA syndrome, and 21 patients with chronic constipation. DKT (0.1-0.15 g\/kg) was mixed with 5\u201310 ml of warm water, and was given orally two to three times a day. DKT was effective for 39 patients (85%) and their clinical symptoms improved. DKT was ineffective in seven patients: two with postoperative ileus, two with Hirschsprung's disease, and three with chronic constipation. DKT had mild but significant effects for various obstructive bowel diseases in children, while no side effects were encountered. Our current strategy for pediatric patients with obstructive bowel disease is to use DKT first and then test its efficacy. If DKT is effective, the regimen is continued. However, in cases where DKT is not effective, we will consider laparotomy or will further investigate the illness. <\/jats:p>","DOI":"10.1142\/s0192415x03000710","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T03:41:30Z","timestamp":1047613290000},"page":"129-135","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Dai-kenchu-to on Obstructive Bowel Disease in Children"],"prefix":"10.1142","volume":"31","author":[{"given":"Toshiki","family":"Ohya","sequence":"first","affiliation":[{"name":"Department of Surgery and Pediatric Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Surgery and Pediatric Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Arii","sequence":"additional","affiliation":[{"name":"Department of Surgery and Pediatric Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Surgery and Pediatric Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, Urayasu Ichikawa  Municipal Hospital, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.5833\/jjgs.28.956"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.35.55"},{"key":"rf3","first-page":"A768","volume":"112","author":"Kurosawa S.","journal-title":"Gastroenterology"},{"key":"rf4","first-page":"285","volume":"32","author":"Muramatsu T.","journal-title":"Jpn. J. Pediatr. Surg."},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.22.1131"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.352"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70033-4"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.3919\/jjsa.61.325"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X03000710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T11:55:12Z","timestamp":1565178912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X03000710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":8,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1142\/S0192415X03000710"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x03000710","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}