{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:12:52Z","timestamp":1761707572654},"reference-count":14,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p> \u03b2-Glucuronidase-inhibitory and hepatoprotective effects of Reduohanxiao-tang (Yuldahanso-tang), which has been used for liver diseases and stroke, on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced hepatotoxicity of rats were investigated. Reduohanxiao-tang potently inhibited \u03b2-glucuronidases. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid dehydrogenase (LDH) levels of the CCl<jats:sub>4<\/jats:sub> group orally treated with Reduohanxiao-tang (100 mg\/kg) were lowered to 54%, 71.5% and 66.1% of the CCl<jats:sub>4<\/jats:sub>-treated control group, respectively. Among the ingredients of the Reduohanxiao-tang, the rhizomes of Pueraria thunbergiana and it Scutellaria baicalensis potently inhibited \u03b2-glucuronidases and protected against CCl<jats:sub>4<\/jats:sub>-induced liver injury. Orally administered puerarin, which is a main component of Pueraria thunbergiana, showed potent hepatoprotective activity, but did not inhibit \u03b2-glucuronidase. However, daidzein, which is produced from puerarin by human intestinal bacteria, potently inhibited \u03b2-glucuronidase. These results suggest that \u03b2-glucuronidase inhibition by herbal medicines may protect a gainst CCl<jats:sub>4<\/jats:sub>-induced liver injury. <\/jats:p>","DOI":"10.1142\/s0192415x03000722","type":"journal-article","created":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T03:41:30Z","timestamp":1047613290000},"page":"111-117","source":"Crossref","is-referenced-by-count":10,"title":["Hepatoprotective Activity of Reduohanxiao-tang  (Yuldahanso-tang) is Related to the Inhibition of \u03b2-Glucuronidase"],"prefix":"10.1142","volume":"31","author":[{"given":"Hyung-Sup","family":"Bae","sequence":"first","affiliation":[{"name":"College of Oriental Medicine, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Sup","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Oriental Medicine, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul, 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Ung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Kyung Hee University, 1 Hoegi, Dongdaemun-ku, Seoul 130-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90210-V"},{"key":"rf2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1248\/yakushi1947.104.1_50","volume":"104","author":"Hayakawa J.","journal-title":"Yakugaku Zasshi"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.17.443"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.21.628"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.1184"},{"key":"rf6","unstructured":"S. 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