{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:16:21Z","timestamp":1767651381385},"reference-count":21,"publisher":"World Scientific Pub Co Pte Lt","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p> As pregnancy advances, prostaglandins (PG) increase in the uterus, leading to elevated uterine contractility. Therefore, regulating the concentration of PG in the uterus can be a key factor for controlling the duration of labor. Since the synthesis of PGs in the uterus is catalyzed by cyclooxygenase-2 (COX-2), devising a tool to regulate the expression of COX-2 could provide a method for treating complicated labor. In this study, Sp-6 acupuncture treatment was evaluated for its potential in controlling uterine motility. Immunohistochemical methods showed the COX-2 enzyme was primarily found in the endometrium and myometrium of rat uterus. COX-2 expression in these two locations were intensified by pregnancy, but reduced by acupuncture at the Sp-6 acupoint. Uterine motility monitored during Sp-6 acupuncture was reduced by 28.15% (p &lt; 0.05) and 19.88% (p &lt; 0.05) in pregnant rats and non-pregnant rats, respectively. The significant reduction of uterine motility in pregnant rat suggests a role for Sp-6 acupuncture in regulating the expression of COX-2 during pregnancy. These results suggest that Sp-6 acupuncture could be used as a complementary method for controlling labor in human pregnancy. <\/jats:p>","DOI":"10.1142\/s0192415x0300117x","type":"journal-article","created":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T10:02:21Z","timestamp":1059991341000},"page":"481-488","source":"Crossref","is-referenced-by-count":8,"title":["Immunohistochemical Localization of Cyclooxygenase-2  in Pregnant Rat Uterus by Sp-6 Acupuncture"],"prefix":"10.1142","volume":"31","author":[{"given":"Jeong-Sang","family":"Kim","sequence":"first","affiliation":[{"name":"School of Oriental Medicine, Dongshin University,  Naju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Su","family":"Na","sequence":"additional","affiliation":[{"name":"School of Oriental Medicine, Dongshin University,  Naju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Jun","family":"Hwang","sequence":"additional","affiliation":[{"name":"School of Oriental Medicine, Wonkwang University,  Iksan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Oriental Medicine, Wonkwang University,  Iksan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Oriental Medicine, Dongshin University,  Naju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok Cheon","family":"Pak","sequence":"additional","affiliation":[{"name":"School of Oriental Medicine, Dongshin University,  Naju, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(79)90101-1"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0630359"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(96)00059-7"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(80)90046-5"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1003228427487"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(90)90112-X"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(91)90060-I"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(73)90115-9"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80402-X"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1159\/000298806"},{"key":"rf11","unstructured":"J.\u00a0O'Connor and D.\u00a0Bensky, Acupuncture Stimulation During Pregnancy: Acupuncture, Obstetric and gynecological diseases, eds. J.\u00a0O'Connor and D.\u00a0Bensky (Eastland Press, Seattle, 1997)\u00a0pp. 668\u2013679."},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X00000064"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02249-X"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70624-1"},{"key":"rf15","first-page":"153","volume":"6","author":"Sananes N.","journal-title":"Mol. Cell. Endocrinol."},{"key":"rf16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-1-4615-5325-0_24","volume":"400","author":"Seibert K.","journal-title":"Adv. Exp. Med. Biol."},{"key":"rf17","first-page":"245","volume":"92","author":"Tempfer C.","journal-title":"Obstet. Gynecol."},{"key":"rf18","first-page":"479","volume":"50","author":"Tsuei J. J.","journal-title":"Obstet. 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