{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:36:56Z","timestamp":1773326216709,"version":"3.50.1"},"reference-count":22,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU.<\/jats:p>","DOI":"10.1142\/s0192415x04001886","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T15:02:06Z","timestamp":1088434926000},"page":"221-234","source":"Crossref","is-referenced-by-count":11,"title":["Immunomodulating Effects of \"Tien-Hsien Liquid\" on Peripheral Blood Mononuclear Cells and T-Lymphocytes from Patients with Recurrent Aphthous Ulcerations"],"prefix":"10.1142","volume":"32","author":[{"given":"Andy","family":"Sun","sequence":"first","affiliation":[{"name":"School of Dentistry, College of Medicine, National Taiwan University, ROC"},{"name":"Institute of Microbiology, College of Medicine, National Taiwan University, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-San","family":"Chia","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Medicine, National Taiwan University, ROC"},{"name":"Institute of Microbiology, College of Medicine, National Taiwan University, ROC"},{"name":"Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won-Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, College of Medicine, National Taiwan University, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Pin","family":"Chiang","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Medicine, National Taiwan University, ROC"},{"name":"Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan, ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","unstructured":"A. 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