{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:49:47Z","timestamp":1760852987752},"reference-count":17,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p> The efficacy and safety of SKI306X, an herbal anti-arthritic agent, was compared with that of diclofenac sodium for the treatment of osteoarthritis of the knee. In a randomized, double-blind, active comparator-controlled trial, a total of 249 patients were randomly assigned to receive either 200 mg of SKI306X three times daily or 100 mg of diclofenac sustained release (SR) once daily. Clinical efficacy variables (visual analog scale, Lesquesne index and global satisfaction score) and adverse events were monitored at baseline and 2nd and 4th weeks of treatment. SKI306X demonstrated efficacy statistically comparable to that of diclofenac, as assessed by the VAS and patients' and investigators' global satisfaction score. Both treatments were well tolerated, however, the SKI306X treatment group experienced less heartburn (4.0% versus 13.7%, p=0.015, chi-square test). In this four-week trial, SKI306X was well tolerated and demonstrated clinical efficacy comparable to that of diclofenac SR. <\/jats:p>","DOI":"10.1142\/s0192415x04001941","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T15:02:06Z","timestamp":1088434926000},"page":"291-301","source":"Crossref","is-referenced-by-count":35,"title":["A Four-Week, Randomized, Double-Blind Trial of the Efficacy and Safety of SKI306X: A Herbal Anti-arthritic Agent versus Diclofenac in Osteoarthritis of the Knee"],"prefix":"10.1142","volume":"32","author":[{"given":"Young-Bok","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Chung-Ang University, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Cheol","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Seoul National University, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung-Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Seoul National University, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Un","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Seoul National University, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Seoul National University, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Man","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-Kuk","family":"Jung","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University and Samsung Medical Center, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai-Gon","family":"Seo","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University and Samsung Medical Center, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn-Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University and Samsung Medical Center, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-Suh","family":"Lee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University and Samsung Medical Center, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwon-Jae","family":"Roh","sequence":"additional","affiliation":[{"name":"Ewha Woman's University Hospital, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Kyun","family":"Han","sequence":"additional","affiliation":[{"name":"Life Science Research Center, SK Chemicals, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Baik","family":"Cho","sequence":"additional","affiliation":[{"name":"Life Science Research Center, SK Chemicals, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don-Yong","family":"Chang","sequence":"additional","affiliation":[{"name":"Life Science Research Center, SK Chemicals, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wie-Jong","family":"Kwak","sequence":"additional","affiliation":[{"name":"Life Science Research Center, SK Chemicals, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui-Oak","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Clinical Research Institute, Seoul National University Hospital, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Clinical Research Institute, Seoul National University Hospital, Seoul 140-757, Korea"},{"name":"Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 140-757, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","first-page":"32","volume":"1","author":"Ahn J. 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