{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:08:50Z","timestamp":1762322930948},"reference-count":26,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Analgesic, antipyretic activity and toxicity study of the leaves of Bryonia laciniosa Linn. (Family: Cucurbitaceae) was evaluated in the standard animal models. The methanol extract of Bryonia laciniosa (MEBL) was evaluated by hot plate and acetic acid-induced writhing methods to assess analgesic activity. The antipyretic activity of the extract was also evaluated by normal body temperature and yeast-induced hyperpyrexia. The extract showed significant analgesic and antipyretic activity. The MEBL was further evaluated for toxicity at the doses of 125 and 250 mg\/kg administered orally for 14 days in rats. At the end of experiments, the blood, liver function and kidney metabolism were observed. The hematological profile and different biochemical parameters such as SGOT, SGPT and ALP were estimated. The present study revealed that MEBL exhibited significant analgesic and antipyretic activity in the tested experimental animal models. The toxicity study indicates that the extract is not toxic at the tested doses.<\/jats:p>","DOI":"10.1142\/s0192415x0400217x","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T10:22:23Z","timestamp":1094552543000},"page":"531-539","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of Analgesic, Antipyretic Activity and Toxicity Study of<i>Bryonia laciniosa<\/i>in Mice and Rats"],"prefix":"10.1142","volume":"32","author":[{"given":"T.","family":"Sivakumar","sequence":"first","affiliation":[{"name":"Natural Products Research Laboratory, J. K. K. Nataraja College of Pharmacy, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Perumal","sequence":"additional","affiliation":[{"name":"Natural Products Research Laboratory, J. K. K. Nataraja College of Pharmacy, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sambath Kumar","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Medicinal Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L. M.","family":"Vamsi","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Medicinal Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gomathi","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Medicinal Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. 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