{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:46:11Z","timestamp":1773661571745,"version":"3.50.1"},"reference-count":22,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p> The protective effects of oleanolic acid (OA) on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced liver mitochondrial damage and the possible mechanisms were investigated. Pretreatment with OA prior to the administration of CCl<jats:sub>4<\/jats:sub> significantly suppressed the increases of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (4.2- and 19.9-fold, respectively) in a dose-dependent manner in mice. The dissipation of mitochondrial membrane potential (14.8%) and intra-mitochondrial Ca <jats:sup>2+<\/jats:sup> overload (2.1-fold) in livers of CCl<jats:sub>4<\/jats:sub>-insulted mice were also dose-dependently prevented by pretreatment with 20, 50 or 100 mg\/kg OA. In addition, the effects of OA on liver mitochondria permeability transition (MPT) induced by Ca <jats:sup>2+<\/jats:sup> were assessed by measuring the change in mitochondrial membrane potential, release of matrix Ca <jats:sup>2+<\/jats:sup> and mitochondrial swelling in vitro. The results showed that preincubation with 50 or 100 \u03bcg\/ml OA obviously inhibited the Ca <jats:sup>2+<\/jats:sup>-induced mitochondrial swelling, mitochondrial membrane depolarization and intra-mitochondrial Ca <jats:sup>2+<\/jats:sup> release. It could be concluded that OA has protective effects on liver mitochondria and the mechanisms underlying its protection may be related to its inhibitory action on MPT. <\/jats:p>","DOI":"10.1142\/s0192415x05003223","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T11:48:38Z","timestamp":1124365718000},"page":"627-637","source":"Crossref","is-referenced-by-count":17,"title":["Hepatoprotection of Oleanolic Acid is Related to Its Inhibition on Mitochondrial Permeability Transition"],"prefix":"10.1142","volume":"33","author":[{"given":"Xin-Hui","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical  Biotechnology and School of Medicine, Nanjing University,  Nanjing, P. R. China"},{"name":"Department of Biology,  Yancheng Teachers College, Yancheng, P. R. 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