{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:01:09Z","timestamp":1769191269817,"version":"3.49.0"},"reference-count":48,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Oxidative stress can be implicated as a cause of liver fibrosis. In this sense, Ginkgo Biloba Extract (EGB), an antioxidant, may be beneficial in restraining liver fibrosis. The aim of this study was to evaluate the effects of EGB on experimental liver fibrosis. Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride ( CCl<jats:sub>4<\/jats:sub>) twice a week for 8 weeks. Three groups of rats received EGB (0.25, 0.5 and 1.0 g\/kg, respectively) by stomach everyday. CCl<jats:sub>4<\/jats:sub>administration induced liver fibrosis, which was inhibited by EGB in a dose-dependent manner. The histopathologic score of fibrosis, liver function and the levels of plasma hyaluronic acid (HA) and laminin (LN) were significantly improved in rats treated with CCl<jats:sub>4<\/jats:sub>+ EGB , compared with those treated with CCl<jats:sub>4<\/jats:sub>only ( p &lt; 0.01 or p &lt; 0.05). The activities of superoxide dismutase (SOD) and glutathione pero xidase (GSH-Px) were notably elevated, while malondialdehyde (MDA) content was significantly decreased in the rats treated with CCl<jats:sub>4<\/jats:sub>+ EGB ( p &lt; 0.01 or p &lt; 0.05). Inhibition of hepatic stellate cell (HSC) activation and nuclear factor kappaBP<jats:sub>65<\/jats:sub>(NF-\u03baBP<jats:sub>65<\/jats:sub>) expression was demonstrated in the livers of EGB-treated rats. The activation of NF-\u03baB was significantly suppressed in EGB-treated rats determined by electrophoretic mobility shift assay (EMSA). Furthermore, EGB reduced expressions of transforming growth factor-\u03b2<jats:sub>1<\/jats:sub>(TGF-\u03b2<jats:sub>1<\/jats:sub>) and collagen I mRNA. In conclusion, EGB is able to ameliorate liver injury and prevent rats from CCl<jats:sub>4<\/jats:sub>-induced liver fibrosis by suppressing oxidative stress. This process may be related to inhibiting the induction of NF-\u03baB on HSC activation and the expression of TGF-\u03b2<jats:sub>1<\/jats:sub>.<\/jats:p>","DOI":"10.1142\/s0192415x06003679","type":"journal-article","created":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T11:15:46Z","timestamp":1138101346000},"page":"99-114","source":"Crossref","is-referenced-by-count":35,"title":["Therapeutic Effects and Molecular Mechanisms of Ginkgo Biloba Extract on Liver Fibrosis in Rats"],"prefix":"10.1142","volume":"34","author":[{"given":"Shi-Quan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Gang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(02)00225-9"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920103"},{"key":"rf3","doi-asserted-by":"crossref","first-page":"G321","DOI":"10.1152\/ajpgi.2000.278.2.G321","volume":"278","author":"Buck M.","journal-title":"Am. 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