{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:05:08Z","timestamp":1784844308481,"version":"3.55.0"},"reference-count":47,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>Chai-Hu-Ching-Kan-Tang (CHCKT) is one of the traditional Chinese medicine prescriptions commonly used to treat liver diseases. In this study, we evaluated the hepatoprotective effects of aqueous CHCKT extract at various concentrations (125, 250 and 500 mg\/kg body weight) on acetaminophen (APAP)-induced acute liver injury in rats. Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups. CHCKT also significantly decreased the level of lipid peroxides and increased the activity of antioxidant enzymes (i.e. SOD and GPx). Histopathological observation further confirmed the hepatoprotective activity of CHCKT as indicated by the amelioration in the central necrosis and fatty changes of the liver after APAP induction. Interestingly, the hepatoprotective activity of CHCKT at concentrations 125~500 mg\/kg appeared to be as good as 12.5 mg\/kg silymarin (a commercial hepatoprotective agent). Taken together, these results suggest that aqueous extract of CHCKT possesses potent hepatoprotective effects agianst APAP-induced liver injury in rats.<\/jats:p>","DOI":"10.1142\/s0192415x07004631","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T19:23:00Z","timestamp":1170444180000},"page":"69-79","source":"Crossref","is-referenced-by-count":6,"title":["Hepatoprotective Effects of<i>Chai-Hu-Ching-Kan-Tang<\/i>on Acetaminophen-Induced Acute Liver Injury in Rats"],"prefix":"10.1142","volume":"35","author":[{"given":"Tzu-Hsiang","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lean-Teik","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Tajen University, Pingtung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Lin","family":"Yen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.565bn.x"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"rf4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","volume":"195","author":"Beers R. 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