{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:52:40Z","timestamp":1782377560233,"version":"3.54.5"},"reference-count":27,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined. PCL extract (25 mg or 50 mg\/kg body weight\/day) was orally administrated to OVX rats for 3 months. PCL extract did not alter weight gain or uterus weight in OVX rats. PCL extract significantly increased serum Ca (calcium) levels ( p &lt; 0.05, vs. OVX group) as well as decreased urinary Ca excretion ( p &lt; 0.05 vs. OVX group) in OVX rats. The upregulation of serum osteocalcin level by ovariectomy was suppressed by treatment with PCL extract in rats ( p &lt; 0.05, vs. OVX group). PCL extract increased bone mineral density at 50 mg\/kg body weight\/day in OVX rats ( p &lt; 0.05, vs. OVX group). Our results indicate that orally administrated PCL extract can decrease urinary calcium excretion and decrease serum osteocalcin in OVX rats, resulting in positive effects on bone mineral density as well as bone formation. In conclusion, our studies showed that PCL might be a potential candidate for treatment of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1142\/s0192415x07005168","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T10:23:08Z","timestamp":1187346188000},"page":"669-680","source":"Crossref","is-referenced-by-count":38,"title":["<i>Psoralea corylifolia<\/i>Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats"],"prefix":"10.1142","volume":"35","author":[{"given":"Meng-Hsiun","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Management Information Systems, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Steven","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Ching","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, China Medical University and Hospital, 91 Hsueh-Shih Road, Taichung 404, Taiwan"},{"name":"Department of Obstetrics and Gynecology, Kuang Tien General Hospital, 117, Sha-Tian Road, Sha-Lu, Taichung 433, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Bin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kuang Tien General Hospital, 117, Sha-Tian Road, Sha-Lu, Taichung 433, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung-Te","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences, China Medical University, 91 Hsueh Shih Road, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hung Kuang University, 34 Chuang-Chie Road, Sha Lu, Taichuang 433, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","first-page":"55","volume":"6","author":"An S. 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