{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:12:37Z","timestamp":1762323157014},"reference-count":44,"publisher":"World Scientific Pub Co Pte Lt","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>In the present study, we investigated the hepatoprotective and antioxidant capacities of ethanol extract of Phellinus merrillii (PM) on carbon tetrachloride-induced hepatotoxicity. In high-performance liquid chromatography (HPLC) analysis, the finger print chromatogram of PM was established. Both hispolon and PM showed a similar peak at the retention time of 6 min. This implied that PM did contain the active ingredient of hispolon. Treatment with PM (0.5, 1 and 2 g\/kg) prior to the administration of carbon tetrachloride (1.5 ml\/kg in olive oil, 20%) significantly prevented the increased serum alanine aminotransferase (s-GOT) and serum aspartate aminotransferase (s-GPT) in a dose-dependent manner. We also found that the incidences of ballooning degeneration, necrosis and portal triaditis were lowered in the group pretreated with PM. Carbon tetrachloride induces up-regulation of antioxidant enzymes, including superoxide dismutase (SOD) (86.6%), catalase (58.8%) and glutathione peroxidase (GPx)(64.7%) in the liver. Pretreatment with PM significantly reduced the all these antioxidant enzyme activities. Therefore, we verified that ethanol extract of PM has the hepatoprotective and antioxidant capacities on rats.<\/jats:p>","DOI":"10.1142\/s0192415x07005272","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T10:16:47Z","timestamp":1193393807000},"page":"793-804","source":"Crossref","is-referenced-by-count":21,"title":["Hepatoprotective and Antioxidant Effects of Ethanol Extract from<i>Phellinus merrillii<\/i>on Carbon Tetrachloride-Induced Liver Damage"],"prefix":"10.1142","volume":"35","author":[{"given":"Heng-Yuan","family":"Chang","sequence":"first","affiliation":[{"name":"Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Huang","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jyh","family":"Sheu","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, College of Medicine, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Jhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu-Chuan","family":"Tseng","sequence":"additional","affiliation":[{"name":"Bureau of Food and Drug Analysis, Department of Health, Executive Yuan, 161-2 Kun-yang St., Nangang District, Taipei City 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Tsung","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, College of Medicine, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hung Kuang University, 34, Chung-Chie Road, Sha Lu, Taichung 433, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan Shiun","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91, Hsueh-Shih Road, Taichung 404, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00042-9"},{"key":"rf3","first-page":"667","volume":"51","author":"Ali N. 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