{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T08:01:34Z","timestamp":1648886494243},"reference-count":31,"publisher":"World Scientific Pub Co Pte Lt","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> We investigated the effects of Chikuyou-Sekkou-To (TJS-167), a traditional Chinese herbal medicine, on changes in eating behavior and rectal temperature induced by administration of tumor necrosis factor-\u03b1 ( TNF -\u03b1) in rats. Infusion of TNF -\u03b1 into the third cerebral ventricle in doses of 1 to 4 \u03bcg\/rat suppressed 24-hour cumulative food and water intake dose-dependently, compared to an infusion of phosphate-buffered saline (PBS) (p &lt; 0.05 for each). The infusion of 2 \u03bcg\/rat TNF -\u03b1 into the third cerebral ventricle elevated rectal temperature compared to PBS controls (p &lt; 0.05). In rats fed diets containing TJS-167 (1.38 g\/kg\/day) for 1 week, the suppressive effect of TNF -\u03b1 (2 \u03bcg\/rat) on food intake was alleviated significantly, compared to rats fed a standard diet (p &lt; 0.05). The elevation of rectal temperature induced by TNF -\u03b1 was attenuated significantly in the TJS-167-treated group compared to the control (p &lt; 0.05). These results indicate that oral administration of TJS-167 may be effective in preventing or reducing TNF -\u03b1-induced inflammatory responses, such as appetite loss and elevation of body temperature. <\/jats:p>","DOI":"10.1142\/s0192415x07005296","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T10:16:47Z","timestamp":1193393807000},"page":"821-829","source":"Crossref","is-referenced-by-count":1,"title":["Chikuyou-Sekkou-To, a Traditional Chinese Herbal Medicine, Modulates Eating Behavior and Thermal Response Induced by Tumor Necrosis Factor-\u03b1 in Rats"],"prefix":"10.1142","volume":"35","author":[{"given":"Seiichi","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 1, School of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiie","family":"Sakata","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Befu, Fukuoka 814-0198, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 1, School of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/oxfordjournals.bmb.a072187","volume":"43","author":"Billingham M. 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