{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:36:24Z","timestamp":1771104984506,"version":"3.50.1"},"reference-count":17,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p> The antioxidant activity and hepatoprotective potential of Cirsium setidens Nakai, a widely used medicinal plant, were investigated. The n-butanol (n-BuOH) fraction of leaves and roots of C. setidens had a higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the other soluble fractions. The n- BuOH fraction of roots of C. setidens had a significant hepatoprotective activity at a dose of 500 mg\/kg compared to that of a standard agent. The biochemical results were confirmed by histological observations indicating that C. setidens extract decreased ballooning degeneration in response to CCl<jats:sub>4<\/jats:sub> treatment. The n-BuOH fraction reduced CCl<jats:sub>4<\/jats:sub>-induced liver injury in rats, and transcript levels of genes encoding antioxidant enzymes such as glutathione peroxidase 1 (GPO1), glutathione peroxidase 3 (GPO3) and superoxide dismutase (SOD1) were elevated in the livers of rats treated with this fraction (500 mg\/kg). Based on these results, we suggest that the C. setidens extract has hepatoprotective effect related to its antioxidant activity. <\/jats:p>","DOI":"10.1142\/s0192415x0800562x","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T12:53:26Z","timestamp":1203598406000},"page":"107-114","source":"Crossref","is-referenced-by-count":31,"title":["Antioxidant and Hepatoprotective Activities of <i>Cirsium setidens<\/i> NAKAI against <font>CCl<\/font><sub>4<\/sub>-Induced Liver Damage"],"prefix":"10.1142","volume":"36","author":[{"given":"Sung Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"School of Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, 200-701, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Il","family":"Heo","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, 200-701, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Kangwon-do, 200-701, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jie","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Kangwon National University, Chuncheon, Kangwon-do, 200-701, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong-Hyeon","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, 200-701, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03322.x"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160423"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(74)90420-1"},{"key":"rf4","first-page":"1","volume":"53","author":"Flora S. J.","journal-title":"Cell Mol. Biol."},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400610"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8788"},{"key":"rf7","first-page":"928","volume":"25","author":"Lee W. B.","journal-title":"Arch. Pharm. Res."},{"key":"rf8","volume-title":"Hepatic Toxicity","author":"Mahendale H. M.","year":"1985"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(74)90385-2"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M907022199"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0282(2000)57:3<160::AID-BIP4>3.0.CO;2-1"},{"key":"rf12","first-page":"235","volume":"7","author":"Michiels C.","journal-title":"Free Radic. Biol. Med."},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90787-7"},{"key":"rf14","first-page":"386","volume":"34","author":"Simibe M. M.","journal-title":"J. Hepatol."},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.57.127"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.37.1919"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X0800562X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:54:01Z","timestamp":1565139241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X0800562X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":17,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1142\/S0192415X0800562X"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x0800562x","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}