{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:42:29Z","timestamp":1771062149490,"version":"3.50.1"},"reference-count":26,"publisher":"World Scientific Pub Co Pte Lt","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p> Glossodynia, or tongue pain, is resistant to conventional therapies. Kampo medicines were evaluated in patients suffering from incurable glossodynia. Patients were diagnosed by traditional Chinese medicine (TCM) theory in order to determine the appropriate herbal prescriptions. Five Japanese females (50\u201376 years old) with glossodynia refractory to conventional therapy were enrolled in this study. Small portions of Rikkunshito, Jiinkokato, Hachimijiogan and Ryutanshakanto worked for a female diagnosed with \"Spleen\" and \"Heart\" Yin deficiency, \"Kidney\" Yang deficiency and \"Liver\" Qi stagnation producing heat syndrome. Seishoekkito and Bakumondoto were effective for a patient diagnosed with \"Spleen Qi\" deficiency and \"Stomach\" Yin deficiency producing heat syndrome. Rikkunshito, Kamikihito and Chikujountanto worked for a patient diagnosed with \"Spleen Qi\" and \"Heart Yin\" deficiency, stagnation of \"Liver\" Qi producing fire and \"Gallbladder\" Qi deficiency. Rokumijiogan, Kamishoyosan and Kambakutaisoto were effective for a patient with Yang rise based on Yin deficiency of \"Kidney\" and \"Liver,\" and restless organ disorder based on Yin deficiency of 5 viscera. A patient diagnosed with \"Spleen\" Yang deficiency responded to a combination of Anchusan and Hangeshashinto. These patients with glossodynia had resolution of pain within 1 month of treatment. Herbal mixtures containing Ganoderam lucidum, not prescribed based on TCM theory, but effective for herpes virus infection, worked for a female suffering from glossodynia for 1 year after artificial teeth were placed, but required about 5 months to note improvement. Kampo medicines, properly prescribed based on TCM theory, quickly resolved the pain of refractory glossodynia. <\/jats:p>","DOI":"10.1142\/s0192415x08006284","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T11:44:17Z","timestamp":1228131857000},"page":"835-847","source":"Crossref","is-referenced-by-count":12,"title":["Kampo Medicine, Based on Traditional Medicine Theory, in Treating Uncured Glossodynia: Efficacy in Five Clinical Cases"],"prefix":"10.1142","volume":"36","author":[{"given":"Yasuyo","family":"Hijikata","sequence":"first","affiliation":[{"name":"Toyodo Hijikata Clinic, Ibaraki City, Osaka, 5670031, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Makiura","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Kitaosaka Police Hospital, Ibaraki City, Osaka, 5670052, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kano","sequence":"additional","affiliation":[{"name":"Medical Corporation Kano Clinic, Osaka City, Osaka, 5420073, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumi","family":"Higasa","sequence":"additional","affiliation":[{"name":"Awaji Oriental Medicine Research attached to Kawasaki Clinic, Minamiawaji City, Hyogo, 6560428, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Shimizu Clinic, Takeo City, Saga, 8430024, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Kawata","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Foundation of Osaka, Osaka City, Osaka, 5420082, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mine","sequence":"additional","affiliation":[{"name":"Mine Clinic, Ibaraki City, Osaka, 5670032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","volume-title":"Chinese Herbal Medicine: Formulas and Strategies","author":"Bensky D.","year":"1990"},{"key":"rf2","volume-title":"Chinese Herbal Medicine: Materia Medica","author":"Bensky D.","year":"1993"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01306_17.x"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200009)62:1<42::AID-JMV7>3.0.CO;2-C"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80347-7"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008049117811"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X98000415"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.6297"},{"key":"rf9","first-page":"268","volume":"27","author":"Hosohara M.","journal-title":"J. Gifu Dent. Soc."},{"key":"rf10","first-page":"437","volume":"51","author":"Hyodo I.","journal-title":"Jpn. J. Orient. Med."},{"key":"rf11","first-page":"278","volume":"53","author":"Kimura T.","journal-title":"J. Jpn. Kampo Med."},{"key":"rf12","first-page":"9","volume":"24","author":"Kitahara T.","journal-title":"J. Jpn. Dent. Soc. Orient. Med."},{"key":"rf13","first-page":"1163","volume":"46","author":"Miyazaki Z.","journal-title":"J. Kampo Med."},{"key":"rf14","first-page":"1265","volume":"49","author":"Miyazaki Z.","journal-title":"J. Kampo Med."},{"key":"rf15","first-page":"22","volume":"11","author":"Nagai I.","journal-title":"Pain Kampo Med."},{"key":"rf16","first-page":"21","volume":"4040","author":"Nagai T.","journal-title":"Jpn. Med. J."},{"key":"rf17","first-page":"945","volume":"41","author":"Nakayama T.","journal-title":"J. Jpn. Med. Assoc."},{"key":"rf18","unstructured":"K.\u00a0Otsuka and D.\u00a0Yakazu, Keiken. Kampo-syoho-bunryosyu (Ido-No-Nippon Sha Inc., Yokohama, 1977)\u00a0p. 109."},{"key":"rf19","first-page":"373","volume":"32","author":"Sakuma Y.","journal-title":"J. Jpn. Dent. Soc. Anesthesiol."},{"key":"rf20","first-page":"55","volume":"58","author":"Suzuki K.","journal-title":"Entoni"},{"key":"rf21","first-page":"847","volume":"18","author":"Ueda Y.","journal-title":"J. Dent. Med."},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X07004928"},{"key":"rf23","volume-title":"WHO International Standard Terminologies on Traditional Medicine in the Western Pacific Region","year":"2007"},{"key":"rf24","first-page":"132","volume":"9","author":"Yasuhara A.","journal-title":"Altern. Ther. Health Med."},{"key":"rf25","first-page":"86","author":"Yasui H.","journal-title":"J. Kampo Acupunct. Integr. Med. (KAIM)"},{"key":"rf26","first-page":"101","author":"Yasui H.","journal-title":"J. Kampo Acupunct. Integr. Med. (KAIM)"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X08006284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:53:02Z","timestamp":1565139182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X08006284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":26,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2012,4,5]]},"published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1142\/S0192415X08006284"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x08006284","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}