{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:14:43Z","timestamp":1782792883077,"version":"3.54.5"},"reference-count":42,"publisher":"World Scientific Pub Co Pte Ltd","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>The effects of extract of Paederia scandens (LOUR.) MERRILL (Rubiaceae) (EPS), a Chinese traditional herbal medicine, on inflammatory and immune responses and their mechanisms in MSU crystals-induced (GA) rats were studied. GA rats were established. Ankle joint volume of rats was measured by volume meter; the level of TNF-\u03b1 and IL-1\u03b2 was determined by radioimmunoassay. mRNA expressions of TNF-\u03b1 and IL-1\u03b2 in synovial tissue of GA rats were analyzed by RT-PCR, and the expression of NF-\u03baB was detected by immunohistochemistry. The administration of EPS (2.25, 4.5 g\/kg, ig 9 days) inhibited the inflammatory response in GA rats. The mRNA expressions of TNF-\u03b1 and IL-1\u03b2 were also significantly suppressed in synovial tissue. In addition, EPS (2.25, 4.5 g\/kg, ig 9 days) inhibited the expression of TNF-\u03b1 and IL-1\u03b2 and the biological activity of NF-\u03baB. These results suggested that EPS possesses antiinflammatory effects by modulating pro-inflammatory mediators' production in synovial tissue and inactivating NF-\u03baB pathway transmembrane signal transduction which plays a crucial role in the pathogenesis of this disease.<\/jats:p>","DOI":"10.1142\/s0192415x09007156","type":"journal-article","created":{"date-parts":[[2009,8,3]],"date-time":"2009-08-03T09:37:53Z","timestamp":1249292273000},"page":"669-683","source":"Crossref","is-referenced-by-count":27,"title":["Effects of Extracts from<i>Paederia scandens<\/i>(LOUR.)<i>MERRILL<\/i>(Rubiaceae) on MSU Crystal-Induced Rats Gouty Arthritis"],"prefix":"10.1142","volume":"37","author":[{"given":"Ying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3140380"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001041"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371207"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.4.323"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28075"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)90072-8"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.13.4557"},{"key":"rf9","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.4049\/jimmunol.138.10.3213","volume":"138","author":"Di Giovine F. 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