{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:59:31Z","timestamp":1791975571629,"version":"4.4.0"},"reference-count":37,"publisher":"World Scientific Pub Co Pte Ltd","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>This study investigates the hepatoprotective activity of ethanol extract from Shidagonglao roots (SDGL<jats:sub>EtOH<\/jats:sub>). The hepatoprotective effect of SDGL<jats:sub>EtOH<\/jats:sub>(20, 100 and 500 mg\/kg) was analyzed on carbon tetrachloride ( CCl<jats:sub>4<\/jats:sub>)-induced acute liver injury. Rats pretreated orally with SDGL<jats:sub>EtOH<\/jats:sub>(100 and 500 mg\/kg) and silymarin (200 mg\/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl<jats:sub>4<\/jats:sub>(0.10 ml\/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl<jats:sub>4<\/jats:sub>-treated rats. Histological analysis also showed that SDGL<jats:sub>EtOH<\/jats:sub>(100 and 500 mg\/kg) and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl<jats:sub>4<\/jats:sub>in rats. Moreover, the SDGL<jats:sub>EtOH<\/jats:sub>(100 and 500 mg\/kg) increased the activities of anti-oxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl<jats:sub>4<\/jats:sub>-treated group. Furthermore, SDGL<jats:sub>EtOH<\/jats:sub>(100 and 500 mg\/kg) and silymarin attenuated the increased levels of tumor necrosis factor-\u03b1 (TNF-\u03b1) in serum and nitric oxide ( NO ) in liver as compared to the CCl<jats:sub>4<\/jats:sub>-treated group. The hepatoprotective mechanisms of SDGL<jats:sub>EtOH<\/jats:sub>are likely related to inhibition of TNF-\u03b1, MDA and NO productions via increasing the activities of antioxidant enzymes (SOD, GPx and GRd). These experimental results suggest that SDGL<jats:sub>EtOH<\/jats:sub>can attenuate CCl<jats:sub>4<\/jats:sub>-induced acute liver injury in rats.<\/jats:p>","DOI":"10.1142\/s0192415x0900751x","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T16:50:35Z","timestamp":1258649435000},"page":"1085-1097","source":"Crossref","is-referenced-by-count":15,"title":["Hepatoprotective Effect of<i>Shidagonglao<\/i>on Acute Liver Injury Induced by Carbon Tetrachloride"],"prefix":"10.1142","volume":"37","author":[{"given":"Jung","family":"Chao","sequence":"first","affiliation":[{"name":"Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Shiou","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Amagaya","sequence":"additional","affiliation":[{"name":"Department of Kampo Pharmaceutical Sciences, Nihon Pharmaceutical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Wang","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Kang","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, National Yang-Ming University, School of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Huang","family":"Peng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00157-4"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.10.029"},{"key":"rf3","first-page":"167","volume":"216","author":"Brouckaert P.","journal-title":"Curr. 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