{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:54:48Z","timestamp":1792634088841,"version":"4.5.0"},"reference-count":38,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p> Curcumin and saikosaponin A as antioxidants improve antioxidant status. This study investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A on CCl<jats:sub>4<\/jats:sub> -induced liver damage. Sprague-Dawley rats were randomly divided into control, CCl<jats:sub>4<\/jats:sub> , CCl<jats:sub>4<\/jats:sub>+ curcumin (0.005%; CU), CCl<jats:sub>4<\/jats:sub> + saikosaponin A (0.004%; SS), and CCl<jats:sub>4<\/jats:sub> + curcumin + saikosaponin A (0.005% + 0.004%; CU + SS) groups. Carbon tetrachloride (40% in olive oil) at a dose of 0.75 ml\/kg was injected intraperitoneally once a week. Curcumin and saikosaponin A were supplemented alone or in combination with diet 1 week before CCl<jats:sub>4<\/jats:sub> injection for 8 weeks. After 8-week supplementation, histopathological results showed hepatic collagen deposition was significantly reduced in the CU and SS groups, and activated nuclear factor-\u03ba B expression induced by CCl<jats:sub>4<\/jats:sub> in the liver was significantly inhibited by curcumin and\/or saikosaponin A. Hepatic proinflammatory cytokines tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interleukin-6 were significantly inhibited, and anti-inflammatory cytokine interleukin-10 was significantly increased by supplementation with curcumin and\/or saikosaponin A. Additionally, curcumin and\/or saikosaponin A significantly reduced the increased levels of hepatic transforming growth factor-\u03b21 and hydroxyproline after CCl<jats:sub>4<\/jats:sub> treatment. Therefore, supplementation with curcumin and\/or saikosaponin A suppress inflammation and fibrogenesis in rats with CCl<jats:sub>4<\/jats:sub> -induced liver injury. However, the combination has no additive effects on anti-inflammation and antifibrosis. <\/jats:p>","DOI":"10.1142\/s0192415x10007695","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T07:14:16Z","timestamp":1265181256000},"page":"99-111","source":"Crossref","is-referenced-by-count":104,"title":["Curcumin and Saikosaponin A Inhibit Chemical-Induced Liver Inflammation and Fibrosis in Rats"],"prefix":"10.1142","volume":"38","author":[{"given":"Shu-Ju","family":"Wu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Nursing, Chang Gung Institute of Technology, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Wai","family":"Tam","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan"},{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.-J.","family":"Chao","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","unstructured":"B. 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