{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:52Z","timestamp":1780099252105,"version":"3.54.0"},"reference-count":30,"publisher":"World Scientific Pub Co Pte Lt","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p> Freshwater clam is traditionally used as a food and has been mentioned in ancient books to have a hepatoprotective effect. The hepatoprotective effect of freshwater clam extract was evaluated in the model of chronic hepatic fibrosis induced by carbon tetrachloride ( CCl<jats:sub>4<\/jats:sub> ). Male Sprague-Dawley rats were orally treated with freshwater clam extract (0.3, 0.6 and 1.5 g\/kg of bw) or silymarin (0.2 g\/kg of bw) along with the administration of CCl<jats:sub>4<\/jats:sub> (0.5 ml\/rat, 20% CCl<jats:sub>4<\/jats:sub> in olive oil) for eight consecutive weeks. Blood samples were collected for assaying serum biochemical parameters. The livers were excised for evaluating peroxidation products and antioxidant substances, as well as the activities of antioxidant enzymes. Pathological histology was also performed. The data showed that supplementation of freshwater clam extract (0.6 g\/kg bw) significantly reduced the serum levels of alanine aminotransferase and aspartate aminotransferase in rats treated with CCl<jats:sub>4<\/jats:sub> , and also decreased the thiobarbituric acid reactive substances, hydroxyproline and excessive inflammation in the livers of CCl<jats:sub>4<\/jats:sub> -treated rats. Histopathological analysis of the liver showed that freshwater clam extract (0.6 g\/kg bw) markedly reduced the injury score of the fibrosis induced by CCl<jats:sub>4<\/jats:sub> in rats. The data suggest that oral administration with freshwater clam extract might provide a novel and alternative approach for treating chronic liver failure. <\/jats:p>","DOI":"10.1142\/s0192415x10008329","type":"journal-article","created":{"date-parts":[[2010,9,6]],"date-time":"2010-09-06T05:28:29Z","timestamp":1283750909000},"page":"881-894","source":"Crossref","is-referenced-by-count":44,"title":["Hepatoprotection by Freshwater Clam Extract Against <font>CCl<sub>4<\/sub><\/font>-Induced Hepatic Damage in Rats"],"prefix":"10.1142","volume":"38","author":[{"given":"Chin-Lin","family":"Hsu","sequence":"first","affiliation":[{"name":"School of Nutrition, Chung Shan Medical University, Taiwan"},{"name":"Department of Nutrition, Chung Shan Medical University Hospital, No. 110, Section 1, Jianguo North Road, Taichung 40201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gow-Chin","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2012,4,5]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"rf3","first-page":"159","volume":"41","author":"Chen C. 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