{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:00:47Z","timestamp":1773237647921,"version":"3.50.1"},"reference-count":42,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p> Yukmijihwangtang (YM), a boiled extract of medicinal plants, has been prescribed for patients with kidney dysfunction in Korea; however, the mechanism underlying its therapeutic effects has not been fully elucidated. This study was conducted to evaluate the beneficial effects on bladder function by using modified YM (M-YM), which included Ulmi radicis cortex in addition to the six traditional medicinal plants in YM. Bladder irritation of the rats was caused by intravesical instillation of HCl . The animals were divided into six groups: sham group, cystitis-injury group with no treatment, cystitis-injury group with prednisolone treatment (5 mg\/kg), and cystitis-injury with M-YM treatment (100, 200 or 500 mg\/kg groups). Whole bladders were collected at day eight after injury. Samples were analyzed by histological and immunological examinations. An in vitro study was performed to determine whether M-YM extracts inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production and I \u03ba B phosphorylation in a human uroepithelial cell line of T24 cells. Administration of M-YM notably improved bladder histological changes, and suppressed IL-6\/TNF \u03b1 production and I \u03ba B phosphorylation in a rat model of chronic cystitis. M-YM also inhibited LPS-induced NO production and I \u03ba B phosphorylation in T24 cells. This study suggests that administration of M-YM might be an applicable therapeutic traditional medicine for the treatment of interstitial cystitis. <\/jats:p>","DOI":"10.1142\/s0192415x12500255","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T12:18:30Z","timestamp":1331641110000},"page":"321-334","source":"Crossref","is-referenced-by-count":10,"title":["Modified Yukmijihwangtang Suppresses the Production of Proinflammatory Cytokines in the Intravesical Hydrochloric Acid-Induced Cystitis Rat Model via the NF-\u03baB Pathway"],"prefix":"10.1142","volume":"40","author":[{"given":"Jeong-Won","family":"Lee","sequence":"first","affiliation":[{"name":"Dr Lee's Oriental Clinic, Charles Sturt University, Bathurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok Cheon","family":"Pak","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University, Bathurst, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhee","family":"Jeon","sequence":"additional","affiliation":[{"name":"Dongguk University Research Institute of Biotechnology, Graduate School of Oriental Medicine, Dongguk University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Oriental Medicine, Dongguk University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,4,30]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)62224-9"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"rf3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","volume":"336","author":"Barnes P. 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