{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:21:27Z","timestamp":1775190087798,"version":"3.50.1"},"reference-count":35,"publisher":"World Scientific Pub Co Pte Lt","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p> This study was performed to investigate effects of Curculigo orchioides rhizome (curculiginis rhizome) on acute reflux esophigitis (RE) in rats that are induced by pylorus and forestomach ligation operation. Proinflammatory cytokine, as well as tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2 and IL-6 were all assayed and the expression of TNF-\u03b1 and COX2 analyzed by RT-PCR. The esophagic tissue damage of reflux esophagitis rat was increased compared to that of normal intact group. However, the esophagic damage percentage from the extract of curculiginis rhizoma (ECR) 600 mg\/kg and ECR 300 mg\/kg were significantly lower than that of the RE control group. Administration of \u03b1-tocopherol (30 mg\/kg) and ECR (600 mg\/kg, 300 mg\/kg, and 150 mg\/kg) had a significant effect on the gastric acid pH in rats with induced reflux esophagitis (p &lt; 0.05). The treatment with ECR significantly reduced the production of cytokines TNF-\u03b1, IL-1\u03b2 and IL-6 levels compared to the model group (p &lt; 0.05). The expression of TNF-\u03b1 and COX2 in the intact esophageal mucosa was low while those of the RE control group were significantly higher due to an inflammatory reaction in the esophagus. Compare to the model group, treatment with \u03b1-tocopherol or ECR significantly inhibited the expression levels of COX2 and TNF-\u03b1 in a dose-dependent manner. These results suggest that anti-inflammatory and protective effects of ECR could attenuate the severity of reflux esophagitis and prevent esophageal mucosal damage. <\/jats:p>","DOI":"10.1142\/s0192415x12500929","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T07:25:13Z","timestamp":1355210713000},"page":"1241-1255","source":"Crossref","is-referenced-by-count":14,"title":["Effect of <i>Curculigo orchioides<\/i> on Reflux Esophagitis by Suppressing Proinflammatory Cytokines"],"prefix":"10.1142","volume":"40","author":[{"given":"Sae-Kang","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Histology and Anatomy, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Bae","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Daejeon University, Daejeon 300-716, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Ung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Herbal Biotechnology, College of Herbal Bio Industry, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Lark","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Sangji University, Wonju 220-702, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae-Ha","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu-Il","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Ha","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Herbal Skin Care, College of Herbal Bio Industry, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Soo","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Herbology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"rf1","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1096\/fasebj.4.11.2199284","volume":"4","author":"Akira S.","journal-title":"FASEB J."},{"key":"rf2","unstructured":"\u00a0Anon, The Ayurvedic Pharmacopoeia of India, 1st edn.\u00a04 (Government of India, New Delhi, 2004)\u00a0p. 122."},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.048"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.1.118"},{"key":"rf5","doi-asserted-by":"crossref","first-page":"1010S","DOI":"10.1093\/jn\/131.3.1010S","volume":"131","author":"Borek C.","journal-title":"J. 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