{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:06:47Z","timestamp":1761217607354},"reference-count":32,"publisher":"World Scientific Pub Co Pte Lt","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p> In the present study, active fractions of the methanolic extract of Xanthium strumarium (XS) showing potent cytotoxicity were determined using microculture tetrazolium (MTT) and sulforhodamine B (SRB) assays in selected cancer cell lines. The active fractions viz., chloroform soluble fraction of root (CEXSR), hexane soluble fraction of leaf (HEXSL), hexane soluble fraction of fruits (HEXSF) and chloroform soluble fraction of fruits (CEXSF) of XS were tested in transplantable animal tumor models for their antitumor potential. Dalton's ascitic lymphoma (DLA) cells were used to induce solid and liquid (ascites) tumor in mice. The tumor bearing animals were treated with active fractions at two dose levels (100 and 200 mg\/kg). The antitumor activities of the active fractions in tumor bearing animals were monitored with parameters such as body weight and increase in life-span as well as biochemical and hematological modalities (in the case of liquid tumor). Tumor incidence and tumor volume were the parameters monitored in the case of the solid tumor model. The results were analyzed by one-way ANOVA followed by Tukey's post hoc test. The extracts were found to increase the life-span of tumor bearing animals and restore the altered hematological and biochemical parameters significantly. <\/jats:p>","DOI":"10.1142\/s0192415x13500110","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T01:29:09Z","timestamp":1358818149000},"page":"145-162","source":"Crossref","is-referenced-by-count":17,"title":["Preliminary Evaluation of <i>In Vitro<\/i> Cytotoxicity and <i>In Vivo<\/i> Antitumor Activity of <i>Xanthium strumarium<\/i> in Transplantable Tumors in Mice"],"prefix":"10.1142","volume":"41","author":[{"given":"Jesil Mathew","family":"Aranjani","sequence":"first","affiliation":[{"name":"Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atulya","family":"Manuel","sequence":"additional","affiliation":[{"name":"Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chamallamudi","family":"Mallikarjuna Rao","sequence":"additional","affiliation":[{"name":"Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayanabhirama","family":"Udupa","sequence":"additional","affiliation":[{"name":"Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josyula Venkata","family":"Rao","sequence":"additional","affiliation":[{"name":"Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal 576104, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Mary","family":"Joy","sequence":"additional","affiliation":[{"name":"Biocon Biopharmaceuticals Pvt. Ltd., Biocon Park, Plot No. 2-4, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajay","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Biocon Biopharmaceuticals Pvt. Ltd., Biocon Park, Plot No. 2-4, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethiraj Kannat","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Advance Sciences, VIT University, Vellore 632014, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2013,1,21]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.3181\/0902-MR-78"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.11.012"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-004-6049-9"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-011-1269-5"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1016\/S1387-2656(05)11004-7"},{"key":"rf6","first-page":"108","volume":"56","author":"Bisht N.","year":"1979","journal-title":"Indian. Chem. Soc."},{"key":"rf7","first-page":"936","volume":"47","author":"Carmichael J.","year":"1987","journal-title":"Cancer. Res."},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-007-0138-9"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1099937"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1177\/33.1.2578146"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.4103\/0973-8258.69154"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.94"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38879"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90029-4"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600630736"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(87)90070-8"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.2174\/0929867013372094"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.01.017"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60413-3"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2011.05.001"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1139\/Y07-104"},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97430-2"},{"key":"rf24","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959537"},{"key":"rf25","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"rf26","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(63)90513-4"},{"key":"rf27","unstructured":"M.\u00a0Suffness and J. M.\u00a0Pezzuto, Methods in Plant Biochemistry: Assays for Bioactivity, ed. K.\u00a0Hostettmann (Academic Press, London, 1990)\u00a0pp. 71\u2013133."},{"key":"rf28","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01313-X"},{"key":"rf29","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.179"},{"key":"rf30","first-page":"2515","volume":"51","author":"Vistica D. T.","year":"1991","journal-title":"Cancer Res."},{"key":"rf31","first-page":"39","volume":"110","author":"Voigt W.","year":"2005","journal-title":"Methods Mol. Med."},{"key":"rf32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11914"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X13500110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T23:09:59Z","timestamp":1565132999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X13500110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":32,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2013,1,21]]},"published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1142\/S0192415X13500110"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x13500110","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}