{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:29:01Z","timestamp":1745987341801,"version":"3.40.4"},"reference-count":20,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Valproic acid (VPA), an anti-epileptic drug with a narrow therapeutic index, is a substrate of the monocarboxylate transporter (MCT). In this study, we investigated the effect of Gegen-Qinlian-Tang (GQT), a Chinese Medicine prescription containing Puerariae Radix (PR), Scutellariae Radix (SR), Coptidis Rhizoma (CR) and Glycyrrhizae Radix (GR), on the pharmacokinetics of VPA, as a probe drug of MCT, in rats and the underlying mechanism. Sprague\u2013Dawley rats were orally administered VPA with and without GQT in crossover design. The serum concentrations of VPA were determined by a fluorescence polarization immunoassay. The results showed that coadministration with 2.0 and 4.0 g\/kg of GQT remarkably decreased the C<jats:sub>max<\/jats:sub>of VPA by 72% and 74% and reduced the AUC<jats:sub>0-t<\/jats:sub>by 63% and 53%, respectively. The mechanism study using Caco-2 cells revealed that the uptake function of MCT was inhibited by GQT and each component herb. In conclusion, the MCT-mediated absorption of VPA was significantly decreased by GQT and its component herbs.<\/jats:p>","DOI":"10.1142\/s0192415x13500274","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T02:49:35Z","timestamp":1364957375000},"page":"369-378","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of Monocarboxylate Transporter-Mediated Absorption of Valproic Acid by Gegen-Qinlian-Tang"],"prefix":"10.1142","volume":"41","author":[{"given":"Hsueh-Jung","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan 40447, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan 40442, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yow-Wen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan 40447, R.O.C."},{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan 40442, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Yuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan 40442, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chi","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital, Taichung, Taiwan 40447, R.O.C."},{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan 40442, R.O.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.465"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016295329865"},{"key":"rf3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1590\/S0100-879X2009000900008","volume":"42","author":"Cherdshewasart W.","year":"2009","journal-title":"Braz. 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