{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:02:56Z","timestamp":1790884976540,"version":"4.1.0"},"reference-count":28,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> Myocardial dysfunction, a common complication after sepsis, significantly contributes to the death of patients with septic shock. In the search for potentially effective drugs to decrease mortality from sepsis, we investigated the cardioprotective effects of baicalein, a flavonoid present in the root of Scutellaria baicalensis, on lipopolysaccharide (LPS)-induced pro-inflammatory cytokine production and matrix metalloproteinase-2 and -9 (MMP-2\/-9) expression. We found that baicalein significantly attenuated LPS-induced cardiac hypertrophy and counteracted reactive oxygen species (ROS) generation in neonatal rat cardiomyocytes. In addition, pretreatment with baicalein inhibited LPS-induced early (e.g., tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6) and late (e.g., high mobility group box 1 (HMGB1) pro-inflammatory cytokine release, inducible nitric oxide synthase (iNOS) expression and NO production. Finally, baicalein also significantly down-regulated the expression of MMP-2\/-9 and attenuated HMGB1 translocation from the nucleus to the cytoplasm. These results suggest that baicalein can protect cardiomyocytes from LPS-induced cardiac injury via the inhibition of ROS and inflammatory cytokine production. These cardioprotective effects are possibly mediated through the inhibition of the HMGB1 and MMP-2\/-9 signaling pathways. <\/jats:p>","DOI":"10.1142\/s0192415x14500505","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T05:59:03Z","timestamp":1404885543000},"page":"785-797","source":"Crossref","is-referenced-by-count":30,"title":["Baicalein Inhibits HMGB1 Release and MMP-2\/-9 Expression in Lipopolysaccharide-Induced Cardiac Hypertrophy"],"prefix":"10.1142","volume":"42","author":[{"given":"Huai-Min","family":"Chen","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Fen","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hau","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Paediatrics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Paediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsan-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaw-Chi","family":"Chiu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jwu-Lai","family":"Yeh","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"},{"name":"Department and Graduate Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.07.002"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500237"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00594-9"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.11.025"},{"key":"rf5","first-page":"486","volume":"31","author":"Ding H. 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