{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:47:22Z","timestamp":1773013642882,"version":"3.50.1"},"reference-count":35,"publisher":"World Scientific Pub Co Pte Lt","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> Type 2 diabetes patients have an increased risk of developing hepatic fibrosis. Salvianolic acid A (SalA) has been reported to be a strong polyphenolic anti-oxidant and free radical scavenger. The aim of the present study was to evaluate the effect of SalA on the pathological progression of hepatic fibrosis in high-fat diet (HFD)-fed and streptozotocin (STZ)-induced diabetic rats and to clarify the underlying mechanisms. Type 2 diabetic animal model with hepatic fibrosis was developed by a high-sucrose, HFD and low-dose STZ injection (i.p.). Diabetic rats were randomly divided into SalA group (0.3 mg\/kg\/day) and diabetic control groups fed with a HFD. After administration for four months, SalA reversed the hyperlipidemia and reduced hepatic triglyceride (TG). Hematoxylin\u2013Eosin (HE) and Picro acid-Sirius red staining results indicated that SalA significantly alleviated the lesions of hepatic steatosis and fibrosis, with the reduction of type I and III collagens. The expression of \u03b1-smooth-muscle-actin (\u03b1-SMA) and transforming growth factor \u03b21 (TGF-\u03b21) in the liver were markedly down-regulated by SalA treatment. TUNEL staining showed that SalA reduced apoptosis in hepatocytes. In addition, SalA improved hepatic mitochondrial respiratory function in diabetic rats. Taken together, these findings demonstrated that SalA could prevent the pathological progression of hepatic fibrosis in HFD-fed and STZ-induced diabetic rats. The underlying mechanisms may be involved in reducing oxidative stress, suppressing \u03b1-SMA and TGF-\u03b21 expression, as well as exerting anti-apoptotic and mitochondria-protective effects. <\/jats:p>","DOI":"10.1142\/s0192415x14500748","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T10:25:46Z","timestamp":1409739946000},"page":"1183-1198","source":"Crossref","is-referenced-by-count":49,"title":["Salvianolic Acid A Prevents the Pathological Progression of Hepatic Fibrosis in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats"],"prefix":"10.1142","volume":"42","author":[{"given":"Guifen","family":"Qiang","sequence":"first","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuying","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xuan","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bainian","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mian","family":"Zu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiguang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"},{"name":"Beijing Key Laboratory of Drug Target Identification and Drug Screening, Beijing 100050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(92)90168-O"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70590-6"},{"key":"rf3","first-page":"65","volume":"17","author":"Chance B.","year":"1956","journal-title":"Adv. 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