{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:18:53Z","timestamp":1781529533844,"version":"3.54.1"},"reference-count":39,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>We assessed the therapeutic effects of lumbrokinase, a group of enzymes extracted from the earthworm, on peripheral-nerve regeneration using well-defined sciatic nerve lesion paradigms in diabetic rats induced by the injection of streptozotocin (STZ). We found that lumbrokinase therapy could improve the rats' circulatory blood flow and promote the regeneration of axons in a silicone rubber conduit after nerve transection. Lumbrokinase treatment could also improve the neuromuscular functions with better nerve conductive performances. Immunohistochemical staining showed that lumbrokinase could dramatically promote calcitonin gene-related peptide (CGRP) expression in the lamina I\u2013II regions in the dorsal horn ipsilateral to the injury and cause a marked increase in the number of macrophages recruited within the distal nerve stumps. In addition, the lumbrokinase could stimulate the secretion of interleukin-1 (IL-1), nerve growth factor (NGF), platelet-derived growth factor (PDGF), and transforming growth factor-\u03b2 (TGF-\u03b2) in dissected diabetic sciatic nerve segments. In conclusion, the administration of lumbrokinase after nerve repair surgery in diabetic rats was found to have remarkable effects on promoting peripheral nerve regeneration and functional recovery.<\/jats:p>","DOI":"10.1142\/s0192415x15500147","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T07:53:45Z","timestamp":1426751625000},"page":"215-230","source":"Crossref","is-referenced-by-count":14,"title":["Improved Peripheral Nerve Regeneration in Streptozotocin-Induced Diabetic Rats by Oral Lumbrokinase"],"prefix":"10.1142","volume":"43","author":[{"given":"Han-Chung","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Division of Neurosurgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Man","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan"},{"name":"Chinese Medicine Department, E-DA Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherng-Jyh","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Biomedical Informatics, Asia University, Wufeng District, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Biomedical Informatics, Asia University, Wufeng District, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00234.x"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1076"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01891.x"},{"key":"rf4","first-page":"E1","volume":"261","author":"Cameron N. 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