{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:07:14Z","timestamp":1772986034583,"version":"3.50.1"},"reference-count":17,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p> The effects of neferine, a bisbenzylisoquinline alkaloid extracted from the seed embryo of the Chinese traditional medicine Nelumbo nucifera Gaertn, on carbon tetrachloride ( CCl <jats:sub>4<\/jats:sub>)-induced hepatic fibrosis in mice were evaluated. Adult male Kunming mice were administered with CCl <jats:sub>4<\/jats:sub> 1 ml\/kg via intraperitoneal injection twice a week for 8 weeks. At the beginning of the 9th week, mice were treated with normal saline, colchicine (0.1 mg\/kg), and neferine (5, 10, 20 mg\/kg) via intraperitoneal injection once a day for 2 weeks. The liver index and histological examination, plasma ALT\/AST levels, hydroxyproline and TGF-\u03b21 content of liver tissue were examined. In the model group, the liver index, the hydroxyproline content of liver tissue and plasma ALT\/AST levels were increased, and a high expression of TGF-\u03b21 was observed. The abnormal changes could be improved by neferine in a dose-dependent manner. Our data showed that neferine had an antifibrosis effect on CCl <jats:sub>4<\/jats:sub>-induced hepatic fibrosis in mice, possibly partly due to the decreased expression of TGF-\u03b21 in the liver. <\/jats:p>","DOI":"10.1142\/s0192415x15500159","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T07:36:30Z","timestamp":1427182590000},"page":"231-240","source":"Crossref","is-referenced-by-count":27,"title":["Anti-Fibrotic Effects of Neferine on Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice"],"prefix":"10.1142","volume":"43","author":[{"given":"Mo-Si","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Research and Application, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China"},{"name":"The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Hua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China"},{"name":"The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1159\/000337586"},{"key":"rf2","first-page":"237","volume":"117","author":"Constandinou C.","year":"2005","journal-title":"Methods. Mol. Med."},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.10.025"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00666-8"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1246-y"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.047"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.001"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2003.10.005"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.05.089"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1178-6"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.06.004"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1177\/1535370213480741"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00432-X"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-02-0149"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00053"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.11.007"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i26.3330"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X15500159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T05:09:06Z","timestamp":1565154546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X15500159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":17,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2015,4,17]]},"published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1142\/S0192415X15500159"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x15500159","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}