{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:40:51Z","timestamp":1787017251972,"version":"build-2736575974"},"reference-count":36,"publisher":"World Scientific Pub Co Pte Ltd","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Lobelia chinensis Lour (LcL) is a popular herb that has been widely used as folk medicine in China for the treatment of fever, lung cancer, and inflammation for hundreds of years. Recently, several studies have shown that the anti-inflammatory properties were correlated with the inhibition of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-6 (IL-6) from the NF-\u03baB pathway. The aim of this study was to evaluate the anti-oxidative and anti-inflammatory activities of L. chinensis. Both suppressive activities on LPS-induced nitric oxide production in RAW264.7 macrophages in vitro and the acute rat lung injury model in vivo were studied. The results showed that the methanol extract of LcL and its fractions within the range of 62.5\u2013250 \u03bcg\/mL did not induce cytotoxicity (p &lt; 0.001). The ethyl acetate fraction of LcL showed better NO inhibition activity than other fractions. On the other hand, the Lc-EA (62.5, 125, 250 mg\/kg) pretreated rats showed a decrease in the pro-inflammatory cytokines (TNF-\u03b1, IL-\u03b2, IL-6) and inhibited iNOS, COX-2 expression through the NF-\u03baB pathway. These results suggested that L. chinensis exhibited an anti-inflammatory effect through the NF-\u03baB pathways.<\/jats:p>","DOI":"10.1142\/s0192415x15500184","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T03:53:45Z","timestamp":1426737225000},"page":"269-287","source":"Crossref","is-referenced-by-count":37,"title":["Anti-Oxidative and Anti-Inflammatory Effects of\n                    <i>Lobelia chinensis In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1142","volume":"43","author":[{"given":"Kun-Cheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hungkuang University, Taichung 433, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Jhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Shiun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University Hospital, Taichung 404, Taiwan"},{"name":"Chinese Crude Drug Pharmacy, China Medical University Hospital, Taichung 404, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2015,4,17]]},"reference":[{"key":"rf1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X09007259"},{"key":"rf2","doi-asserted-by":"publisher","DOI":"10.1021\/jf201375u"},{"key":"rf3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.11.022"},{"key":"rf4","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)00355-2"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500845"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500407"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035922"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1021\/jf0701786"},{"key":"rf9","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08005783"},{"key":"rf10","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X11009147"},{"key":"rf11","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.908"},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X10007889"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X1100955X"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500754"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500670"},{"key":"rf16","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500747"},{"key":"rf17","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500449"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500772"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500153"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X13500304"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X12500267"},{"key":"rf22","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500554"},{"key":"rf23","first-page":"917","volume":"35","author":"Lv X. 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