{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:39:37Z","timestamp":1769877577017,"version":"3.49.0"},"reference-count":27,"publisher":"World Scientific Pub Co Pte Lt","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p> The prevention and management of type 2 diabetes mellitus has become a major global public health challenge. Decursin, an active compound of Angelica gigas Nakai roots, was recently reported to have a glucose-lowering activity. However, the antidiabetic effect of Angelica gigas Nakai extract (AGNE) has not yet been investigated. We evaluated the effects of AGNE on glucose homeostasis in type 2 diabetic mice and investigated the underlying mechanism by which AGNE acts. Male C57BL\/KsJ-db\/db mice were treated with either AGNE (10 mg\/kg, 20 mg\/kg, and 40 mg\/kg) or metformin (100 mg\/kg) for 8 weeks. AGNE supplementation (20 and 40 mg\/kg) significantly decreased fasting glucose and insulin levels, decreased the areas under the curve of glucose in oral glucose tolerance and insulin tolerance tests, and improved homeostatic model assessment-insulin resistant (HOMA-IR) scores. AGNE also ameliorated hepatic steatosis, hyperlipidemia, and hypercholesterolemia. Mechanistic studies suggested that the glucose-lowering effect of AGNE was mediated by the activation of AMP activated protein kinase, Akt, and glycogen synthase kinase-3[Formula: see text]. AGNE can potentially improve hyperglycemia and hepatic steatosis in patients with type 2 diabetes. <\/jats:p>","DOI":"10.1142\/s0192415x16500919","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T03:16:13Z","timestamp":1479352573000},"page":"1627-1638","source":"Crossref","is-referenced-by-count":21,"title":["<i>Angelica gigas<\/i> Ameliorates Hyperglycemia and Hepatic Steatosis in C57BL\/KsJ-<i>db\/db<\/i> Mice via Activation of AMP-Activated Protein Kinase Signaling Pathway"],"prefix":"10.1142","volume":"44","author":[{"given":"Ui-Jin","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Kyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Ra","family":"Oh","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Chonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Sung","family":"Jung","sequence":"additional","affiliation":[{"name":"Wellbeingproducts Co., Ltd., Gimhae, Gyeongnam 50969, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Wan","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"},{"name":"Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2016,12,6]]},"reference":[{"key":"S0192415X16500919BIB001","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S007"},{"key":"S0192415X16500919BIB002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7008"},{"key":"S0192415X16500919BIB003","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2407-y"},{"key":"S0192415X16500919BIB004","first-page":"241","volume":"7","author":"Coughlan K.A.","year":"2014","journal-title":"Diabetes Metab. 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