{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:41:06Z","timestamp":1787017266252,"version":"build-2736575974"},"reference-count":30,"publisher":"World Scientific Pub Co Pte Ltd","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>To investigate the hepatoprotective effect of Cymbopogon citratus or lemongrass essential oil (LGO), it was used in an animal model of acute liver injury induced by acetaminophen (APAP). Swiss mice were pretreated with LGO (125, 250 and 500[Formula: see text]mg\/kg) and SLM (standard drug, 200[Formula: see text]mg\/kg) for a duration of seven days, followed by the induction of hepatotoxicity of APAP (single dose, 250[Formula: see text]mg\/kg). The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase were determined to evaluate the hepatoprotective effects of the LGO. The livers were used to determine myeloperoxidase (MPO) activity, nitric oxide (NO) production and histological analysis. The effect of LGO on leukocyte migration was evaluated in vitro. Anti-oxidant activity was performed by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro. LGO pretreatment decreased significantly the levels of ALT, AST and ALP compared with APAP group. MPO activity and NO production were decreased. The histopathological analysis showed an improved of hepatic lesions in mice after LGO pretreatment. LGO inhibited neutrophil migration and exhibited anti-oxidant activity. Our results suggest that LGO has protective activity against liver toxicity induced by paracetamol.<\/jats:p>","DOI":"10.1142\/s0192415x17500318","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:06:53Z","timestamp":1490918813000},"page":"515-532","source":"Crossref","is-referenced-by-count":32,"title":["Protective Effect of\n                    <i>Cymbopogon citratus<\/i>\n                    Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury"],"prefix":"10.1142","volume":"45","author":[{"given":"Nancy Sayuri","family":"Uchida","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Euclides","family":"Silva-Filho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Pazinatto","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alexandre Marques","family":"Wiirzler","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Fernando Esteves","family":"Cardia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Augusto Otaviano","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francielli Maria de Souza","family":"Silva-Comar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia Cristina Alexandrino","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Basic Health Science, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Expedito Leite","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciomar Aparecida","family":"Bersani-Amado","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Kenji Nakamura","family":"Cuman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, 87020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"S0192415X17500318BIB001","unstructured":"Adams, R.P. 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