{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:35:40Z","timestamp":1793190940249,"version":"4.5.0"},"reference-count":40,"publisher":"World Scientific Pub Co Pte Lt","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> Platycodin D (PD) is the main active saponin isolated from Platycodon grandiflorum (PG) and is reported to exhibit anticancer, anti-angiogenic, anti-inflammation and anti-obesity biological effects. The current study aims to evaluate the therapeutic efficacy of PD in cardiac fibrosis and for hypertrophy in spontaneous hypertension rats (SHRs) and to verify inhibition of the signaling pathway. Significant increases in the cardiac functional indices of left ventricular internal diameter end diastole (LVIDd) and left ventricular internal diameter end systole (LVIDs); the eccentric hypertrophy marker p-MEK5; concentric hypertrophy markers, such as CaMKII[Formula: see text] and calcineurin; and expression levels of NFATc3, p-GATA4 and BNP were observed in spontaneously hypertensive groups. PD treatment reversed these increases in SHRs. In addition, an increase in the fibrosis markers FGF2, uPA, MMP2, MMP9, TGF[Formula: see text]-1 and CTGF during cardiac hypertrophy was detected by western blotting analyses. These results demonstrated that PD treatment considerably attenuates cardiac fibrosis. Histopathological examination revealed that PD treatment remarkably reduced collagen accumulation in contrast to spontaneously hypertensive groups. This study clearly suggests that PD provides myocardial protection by alleviating two damaging responses to hypertension, fibrosis and hypertrophy, in the heart. <\/jats:p>","DOI":"10.1142\/s0192415x18500271","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T09:52:16Z","timestamp":1522317136000},"page":"537-549","source":"Crossref","is-referenced-by-count":34,"title":["Platycodin D Reverses Pathological Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats"],"prefix":"10.1142","volume":"46","author":[{"given":"Yuan-Chuan","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mei Ho University, Pingtung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan"},{"name":"Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey-Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya V.","family":"Padma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bharathiar University, Coimbatore 641 046, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Translation Research Core, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan"},{"name":"Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"S0192415X18500271BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.02.006"},{"key":"S0192415X18500271BIB002","first-page":"158","volume":"2","author":"Biernacka A.","year":"2011","journal-title":"Aging Dis."},{"key":"S0192415X18500271BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"S0192415X18500271BIB004","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq308"},{"key":"S0192415X18500271BIB005","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00654"},{"key":"S0192415X18500271BIB006","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000121363.08252.a7"},{"key":"S0192415X18500271BIB007","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0345-7"},{"key":"S0192415X18500271BIB008","author":"Huang C.Y.","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"S0192415X18500271BIB009","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25905"},{"key":"S0192415X18500271BIB010","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.356"},{"key":"S0192415X18500271BIB011","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.46"},{"key":"S0192415X18500271BIB012","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.320"},{"key":"S0192415X18500271BIB013","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.10.017"},{"key":"S0192415X18500271BIB014","doi-asserted-by":"publisher","DOI":"10.12965\/jer.130049"},{"key":"S0192415X18500271BIB015","doi-asserted-by":"publisher","DOI":"10.1159\/000430152"},{"key":"S0192415X18500271BIB016","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2011.27.4.217"},{"key":"S0192415X18500271BIB017","doi-asserted-by":"publisher","DOI":"10.1038\/srep37997"},{"key":"S0192415X18500271BIB018","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.357"},{"key":"S0192415X18500271BIB019","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-015-0011-z"},{"key":"S0192415X18500271BIB020","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-016-0018-0"},{"key":"S0192415X18500271BIB021","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2016.0087"},{"key":"S0192415X18500271BIB022","doi-asserted-by":"publisher","DOI":"10.7603\/s40681-015-0005-x"},{"key":"S0192415X18500271BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.04.028"},{"key":"S0192415X18500271BIB024","doi-asserted-by":"publisher","DOI":"10.1021\/jf901405c"},{"key":"S0192415X18500271BIB025","first-page":"934","volume":"13","author":"Liu W.","year":"2014","journal-title":"J. Sports Sci. Med."},{"key":"S0192415X18500271BIB026","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000046452.67724.B8"},{"key":"S0192415X18500271BIB027","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12055"},{"key":"S0192415X18500271BIB028","doi-asserted-by":"publisher","DOI":"10.1007\/BF03086131"},{"key":"S0192415X18500271BIB029","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301667"},{"key":"S0192415X18500271BIB030","doi-asserted-by":"publisher","DOI":"10.1186\/s13069-015-0023-z"},{"key":"S0192415X18500271BIB031","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.6.623"},{"key":"S0192415X18500271BIB032","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.04.030"},{"key":"S0192415X18500271BIB033","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.865-878.2005"},{"key":"S0192415X18500271BIB034","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.190"},{"key":"S0192415X18500271BIB035","first-page":"76","volume":"12","author":"Spadaccio C.","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"S0192415X18500271BIB036","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2010-054"},{"key":"S0192415X18500271BIB037","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017392"},{"key":"S0192415X18500271BIB038","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0827fje"},{"key":"S0192415X18500271BIB039","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-195"},{"key":"S0192415X18500271BIB040","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0089-6"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X18500271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T04:30:19Z","timestamp":1565152219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X18500271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":40,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2018,4,24]]},"published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1142\/S0192415X18500271"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x18500271","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}