{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:51Z","timestamp":1760122791552},"reference-count":45,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> Hominis placenta (HP), a dried human placenta, has been known to target liver, lung, or kidney meridians, improving the functions associated with these meridians in traditional Chinese or Asian medicine (TCM). Since recent studies implicate an HP extract in suppressing inflammation, we investigated whether an aqueous HP extract can ameliorate inflammation that occurred in the lungs. When administered with a single intratracheal lipopolysaccharide (LPS), C57BL\/6 mice developed an acute neutrophilic lung inflammation along with an increased expression of pro-inflammatory cytokine genes. However, this was diminished by the administration HP extract via an intraperitoneal route 2\u2009h after LPS treatment. Western blot and semi-quantitative RT-PCR analyses revealed that while suppressing the activity of a proinflammatory factor NF-[Formula: see text]B marginally, the HP extract strongly activated an anti-inflammatory factor Nrf2, with concomitant expression of Nrf2-dependent genes. Mechanistically, the HP extract suppressed the ubiquitin-mediated degradation of Nrf2, functioning similarly to a 26S proteasome inhibitor, MG132. Collectively, these results suggest that the HP extract suppresses inflammation in mouse lungs, which is in part related to the HP extract perturbing the ubiquitin-dependent degradation of Nrf2 and thus increasing the function of Nrf2. <\/jats:p>","DOI":"10.1142\/s0192415x18500428","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T03:14:22Z","timestamp":1526267662000},"page":"801-817","source":"Crossref","is-referenced-by-count":4,"title":["<i>Hominis placenta<\/i> Suppresses Acute Lung Inflammation by Activating Nrf2"],"prefix":"10.1142","volume":"46","author":[{"given":"Tae Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Lung Cancer Clinic, Pulmonary Medicine Center, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyun Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kwun","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Woo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Korean Medicine Hospital of Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, Division of Health Sciences, Dongseo University, Busan 47011, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myungsoo","family":"Joo","sequence":"additional","affiliation":[{"name":"School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"S0192415X18500428BIB001","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26071"},{"key":"S0192415X18500428BIB002","first-page":"109","volume":"270","author":"Beutler B.","year":"2002","journal-title":"Curr. 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