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Documented data has shown that puerarin has cardio-protective, neuroprotective, anti-oxidative, anti-inflammatory and many other effects. In this review, we will summarize the beneficial effects and underlying mechanisms of puerarin on DM and complications. Puerarin may directly benefit DM by decreasing blood glucose levels, improving insulin resistance, protecting islets, inhibiting inflammation, decreasing oxidative stress and inhibiting Maillard reaction and advanced glycation end products (AGEs) formation. Furthermore, puerarin may also benefit DM indirectly by retarding and improving a series of DM complications, such as cardiovascular complications, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, etc. However, comprehensive studies of its effect and mechanisms are needed. In addition, its efficacy is relatively low, which is partially due to its pharmacokinetics profiles. Though puerarin shows low toxicity to experimental animals, its safety on human remains to be clarified. Collectively, we suggest that puerarin might be a potential adjuvant agent for the treatment of DM and DM complications in future.<\/jats:p>","DOI":"10.1142\/s0192415x18500891","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T07:05:38Z","timestamp":1544511938000},"page":"1771-1789","source":"Crossref","is-referenced-by-count":131,"title":["Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone From<i>Pueraria lobata<\/i>"],"prefix":"10.1142","volume":"46","author":[{"given":"Xiuping","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563003, P. R. 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