{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:59:56Z","timestamp":1793757596592,"version":"4.6.1"},"reference-count":33,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> Red yeast rice (RYR) has been used as an alternative treatment for hyperlipidemia. According to the previous studies, other compounds, besides monacolin K in RYR, may also reduce the serum lipid level. This study aims at examining the efficacy of monacolin K-rich and Gamma-Aminobutyric Acid (GABA)-rich RYR (Monascus pilosus) with regards to treating hyperlipidemia in a randomized control, double-blind clinical trial. In the research, we assigned 50 eligible subjects to monacolin K-rich RYR, GABA-rich RYR and placebo groups ([Formula: see text], 17, 17, respectively). The concentrations of TC, LDL-C, HDL, TG and blood biochemical data were evaluated at different phases: before applying (visit 1), after 1-month (visit 2), 2-month (visit 3), 3-month (visit 4) of providing the intervention and 1-month after ending the test food (visit 5) among three groups. During the 3-month intervention, the serum TC and LDL-C levels decreased significantly in the monacolin K group compared to the baseline and the other two groups. The Serum TG level declined steadily but was not statistically significant. Meanwhile, no marked differences in the serum HDL level were revealed among the three groups. Most safety assessment data had minor variation except two subjects (in monacolin K and GABA group separately) reported elevated liver enzymes. Monacolin K-rich RYR can reduce cholesterol as expected, while the GABA-rich RYR performed non-significant reduction on serum triglyceride. The research results demonstrate that using different concentrations and ratios between monacolin K and GABA could be beneficial for antihyperlipidemia. <\/jats:p>","DOI":"10.1142\/s0192415x19500150","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T03:38:01Z","timestamp":1552621081000},"page":"323-335","source":"Crossref","is-referenced-by-count":37,"title":["A Randomized Clinical Efficacy Trial of Red Yeast Rice (<i>Monascus pilosus<\/i>) Against Hyperlipidemia"],"prefix":"10.1142","volume":"47","author":[{"given":"Tien-Ju","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Shin-Yu","family":"Lien","sequence":"additional","affiliation":[{"name":"School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan"},{"name":"Division of 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