{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:52:29Z","timestamp":1772113949333,"version":"3.50.1"},"reference-count":48,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> This study examined whether serotonin and two of its derivatives, [Formula: see text]-feruloylserotonin and [Formula: see text]-([Formula: see text]-coumaroyl) serotonin, have a renoprotective effect in a mouse model of cisplatin-induced acute renal failure. Cisplatin (20[Formula: see text]mg\/kg body weight) was administered by intraperitoneal injection to male BALB\/c mice that had received oral serotonin, [Formula: see text]-feruloylserotonin or [Formula: see text]-([Formula: see text]-coumaroyl) serotonin (7.5[Formula: see text]mg\/kg body weight per day) during the preceding 2 days. At 3 days after the cisplatin injection, serum and renal biochemical factors, oxidative stress, inflammation and apoptosis-related protein expression were evaluated, and histological examinations were performed. Cisplatin caused reduction in body weight and an increase in kidney weight; however, [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin attenuated these effects. Moreover, the serotonin derivatives significantly decreased serum urea nitrogen and creatinine levels. They also significantly reduced the level of reactive oxygen species and upregulated the expression of glutathione peroxidase in the kidney. Furthermore, the serotonin derivatives improved the abnormal expression of mitogen-activated protein kinases activation-dependent inflammation- and apoptosis-related protein and caused less renal damage. These results provide important evidence that [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin exert a pleiotropic effect on several parameters related to oxidative stress, inflammation and apoptosis. The derivatives also have a renoprotective effect in cisplatin-treated mice; however, this effect is higher with [Formula: see text]-([Formula: see text]-coumaroyl) serotonin. <\/jats:p>","DOI":"10.1142\/s0192415x19500186","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T08:29:01Z","timestamp":1551688141000},"page":"369-383","source":"Crossref","is-referenced-by-count":13,"title":["Protective Effects of Serotonin and its Derivatives, <i>N<\/i>-Feruloylserotonin and <i>N<\/i>-(<i>p<\/i>-Coumaroyl) Serotonin, Against Cisplatin-Induced Renal Damage in Mice"],"prefix":"10.1142","volume":"47","author":[{"given":"Chan Hum","family":"Park","sequence":"first","affiliation":[{"name":"Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369\u2013873, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ah Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Hui","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Food and Life Science, Pukyong National University, Busan 608\u2013737, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ju","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pusan National University, Busan 46241, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Sue","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food and Life Science, Pukyong National University, Busan 608\u2013737, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369\u2013873, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyoung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Yokozawa","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering for Research, University of Toyama, Toyama 930\u20138555, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Su","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369\u2013873, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"S0192415X19500186BIB001","first-page":"637","volume":"13","author":"Ali S.F.","year":"1992","journal-title":"Neurotoxicology"},{"key":"S0192415X19500186BIB002","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0130fje"},{"key":"S0192415X19500186BIB003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00926734"},{"key":"S0192415X19500186BIB004","first-page":"140","volume":"11","author":"Bae S.","year":"2002","journal-title":"Food Sci. 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