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In this paper, we summarize the research progress of triptolide and celastrol (the two major TWHF components) as well as their analogues in the treatment of neurodegenerative diseases. In addition, we review and discuss the molecular mechanisms and structure features of those two bioactive TWHF components, highlighting their therapeutic promise in neurodegenerative diseases.<\/jats:p>","DOI":"10.1142\/s0192415x1950040x","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T01:34:47Z","timestamp":1557970487000},"page":"769-785","source":"Crossref","is-referenced-by-count":49,"title":["Treatment of Neurodegenerative Diseases with Bioactive Components of<i>Tripterygium wilfordii<\/i>"],"prefix":"10.1142","volume":"47","author":[{"given":"Jianheng","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy, Key laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, Hebei, P. R. 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