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Med."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The genus Saururus, belonging to Saururaceae, contains two species, S.\u00a0cernuus L. and S.\u00a0chinensis (Lour) Baill. with common utilization in traditional medicine from Asia to North America for the treatment of edema, beriberi, jaundice, leucorrhea, urinary tract infections, hypertension, hepatitis diseases, and tumors. An extensive review of literature was made on traditional uses, phytochemistry, and ethnopharmacology of Saururus using ethno-botanical books, published articles, and electronic databases. The 147 of chemical constituents have been isolated and identified from S.\u00a0cernuus and S.\u00a0chinensis, and lignans, flavonoids, alkaloids, anthraquinones, saponins, and phenols are the major constituents. Various pharmacological investigations in many in vitro and in vivo models have revealed the potential of the genus Saururus with anti-inflammatory, antitumor, anti-oxidant, hepatoprotective, antimelanogenic, lipid-lowering, and bone protective activities, supporting the rationale behind numerous of its traditional uses. Due to the noteworthy pharmacological properties, Saururus can be a better option for new drug discovery. Data regarding many aspects of this plant such as toxicology, pharmacokinetics, quality-control measures, and the clinical value of the active compounds is still limited which call for additional studies. <\/jats:p>","DOI":"10.1142\/s0192415x20500032","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T21:29:37Z","timestamp":1579642177000},"page":"47-76","source":"Crossref","is-referenced-by-count":29,"title":["A Review of Traditional Uses, Phytochemistry, and Pharmacological Properties of the Genus <i>Saururus<\/i>"],"prefix":"10.1142","volume":"48","author":[{"given":"Guangxin","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource, Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi\u2019an, Shaanxi 710062, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zefeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi\u2019an, Shaanxi 710069, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilun","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource, Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi\u2019an, Shaanxi 710062, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi\u2019an, Shaanxi 710069, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai Road, Xi\u2019an, Shaanxi 710069, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirui","family":"He","sequence":"additional","affiliation":[{"name":"Honghui Hospital, Xi\u2019an Jiaotong University, 76 Nanguo Road, Xi\u2019an, Shaanxi 710054, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource, Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi\u2019an, Shaanxi 710062, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"S0192415X20500032BIB001","doi-asserted-by":"publisher","DOI":"10.1021\/np0006061"},{"key":"S0192415X20500032BIB002","doi-asserted-by":"publisher","DOI":"10.1002\/med.21477"},{"key":"S0192415X20500032BIB003","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12002"},{"key":"S0192415X20500032BIB004","first-page":"443","volume":"36","author":"Chen H.","year":"2017","journal-title":"Lat. 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