{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:20:31Z","timestamp":1755926431656},"reference-count":38,"publisher":"World Scientific Pub Co Pte Lt","issue":"02","funder":[{"name":"the Ministry of Education, Republic of Korea","award":["2017R1A6A1A03015642"],"award-info":[{"award-number":["2017R1A6A1A03015642"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Pharmacological activities of some Leguminosae family members were reported. Pharmacological activities of Archidendron lucidum, a Leguminosae family member have never been explored. Therefore, this study investigated anti-inflammatory effects of an Archidendron lucidum methanol extract (Al-ME). In this study, anti-inflammatory effects of Al-ME were investigated in LPS-stimulated RAW264.7 cells and HCl\/EtOH-induced gastritis mice by MTT assay, nitric oxide (NO) production assay, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), luciferase reporter assay, and Western blotting. High-performance liquid chromatography (HPLC) analysis identified ethnopharmacological compounds in Al-ME. Al-ME inhibited NO production without cytotoxicity in peritoneal macrophages and RAW264.7 cells stimulated with LPS or Pam3CSK4. Al-ME downregulated mRNA expression of inflammatory genes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2)) and pro-inflammatory cytokines (tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and IL-6). Al-ME exerted anti-inflammatory activity in LPS-stimulated RAW264.7 cells by inhibiting nuclear factor-kappa B (NF-[Formula: see text]B) signaling pathway. HPLC analysis identified quercetin, luteolin, and kaempferol as major anti-inflammatory components in Al-ME. Al-ME ameliorated HCl\/EtOH-induced gastritis symptoms in mice by suppressing iNOS and IL-6 mRNA expressions and I[Formula: see text]B[Formula: see text] phosphorylation. Therefore, these results suggest that Al-ME exhibited anti-inflammatory activity by targeting NF-[Formula: see text]B signaling pathway, implying that Al-ME could be potent anti-inflammatory medications to prevent and treat inflammatory diseases. <\/jats:p>","DOI":"10.1142\/s0192415x20500226","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T07:17:51Z","timestamp":1583997471000},"page":"429-444","source":"Crossref","is-referenced-by-count":5,"title":["<i>Archidendron lucidum<\/i> Exerts Anti-Inflammatory Effects by Targeting PDK1 in the NF-\u03baB Pathway"],"prefix":"10.1142","volume":"48","author":[{"given":"Minkyeong","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Su","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Life Science, Kyonggi University, Suwon 16227, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"S0192415X20500226BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.03.003"},{"key":"S0192415X20500226BIB002","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/512926"},{"key":"S0192415X20500226BIB003","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0900676X"},{"key":"S0192415X20500226BIB004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111848"},{"key":"S0192415X20500226BIB005","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054022024"},{"key":"S0192415X20500226BIB006","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(98)00060-6"},{"key":"S0192415X20500226BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.06.003"},{"key":"S0192415X20500226BIB008","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X18500672"},{"key":"S0192415X20500226BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(00)01511-7"},{"key":"S0192415X20500226BIB010","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01346-2"},{"key":"S0192415X20500226BIB011","doi-asserted-by":"publisher","DOI":"10.1159\/000448437"},{"key":"S0192415X20500226BIB012","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6256"},{"key":"S0192415X20500226BIB013","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.083001.084359"},{"key":"S0192415X20500226BIB014","first-page":"3909038","volume":"2018","author":"Kim H.G.","year":"2018","journal-title":"Evid. 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