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Med."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> As a long-established medicinal and edible homologous plant, Taraxacum officinale Wigg. is widely distributed in Asia, Europe, and other parts of the world. T. officinale is reported to exert a variety of biological and pharmacological activities, including anticancer, hepatoprotective, and anti-obesity effects. In this study, we evaluated the anti-inflammatory effects of ethanol extracts of T. officinale (A-TOW) by examining the suppression of proinflammatory mediators in LPS-stimulated BV2 and mouse hippocampus. Furthermore, A-TOW also inhibited the nuclear translocation of nuclear factor [Formula: see text]B p65 caused by stimulation with LPS. In addition, A-TOW regulates heme oxygenase (HO)-1 expression through the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in BV2 cells. The effects of A-TOW on the over-expression of proinflammatory mediators were partially reversed by transfection of the cells with HO-1 siRNA. These findings suggest that the potent anti-inflammatory activity of T. officinale, possibly through the regulation of Nrf2\/HO-1 and NF-[Formula: see text]B signaling pathway. <\/jats:p>","DOI":"10.1142\/s0192415x20500238","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:04:33Z","timestamp":1583478273000},"page":"445-462","source":"Crossref","is-referenced-by-count":11,"title":["<i>Taraxacum officinale<\/i> Wigg. 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