{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:18:43Z","timestamp":1793121523923,"version":"4.5.0"},"reference-count":77,"publisher":"World Scientific Pub Co Pte Ltd","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Fucoidan is a type of polysaccharide rich in sulfuric acid groups and is mainly found in brown algae. Due to its extensive biological activities, such as anticoagulant, antitumor, antithrombotic, antiviral, anti-oxidant and enhancing immune function, fucoidan has gradually become a research hotspot. Under the scientific guidance of modern medical theory, fucoidan and its mechanism in oxidative stress, carbohydrate and lipid metabolism, inflammatory response, tumor proliferation, and metastasis have become a new research direction and an important basis as an effective liver protection drug. In this paper, we discuss the important role of fucoidan in viral hepatitis, liver fibrosis, liver cancer, nonalcoholic fatty liver and liver injury induced by drugs and ischemia and briefly discuss its underlying mechanism. We supplement the theoretical basis for its clinical application and provide effective targets for the development of follow-up dominant drugs.<\/jats:p>","DOI":"10.1142\/s0192415x20500809","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T07:59:34Z","timestamp":1604563174000},"page":"1617-1632","source":"Crossref","is-referenced-by-count":32,"title":["Fucoidan: Biological Activity in Liver Diseases"],"prefix":"10.1142","volume":"48","author":[{"given":"Jingjing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Putuo People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200060, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Shanghai 200072, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Putuo People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200060, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"S0192415X20500809BIB001","author":"Abdel-Daim M.M.","year":"2020","journal-title":"Environ. 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