{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:56:19Z","timestamp":1770281779054,"version":"3.49.0"},"reference-count":61,"publisher":"World Scientific Pub Co Pte Lt","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> This study aimed to verify the efficacy of a combined treatment of Jakyakgamcho-tang (JGT) and acupuncture (CV12, ST25, CV4) on colitis induced by dextrane sulfate sodium (DSS). Changes in immuno-mediated factors and metabolites were investigated. Colitis symptoms such as body weight loss and elevated disease activity index were alleviated by the combined treatment. Moreover, treatment with JGT and acupuncture restored the disturbed architecture of colon by suppressing inflammatory cytokine levels of IFN-[Formula: see text] ([Formula: see text] &lt; 0.05), IL-5 ([Formula: see text] &lt; 0.05), and IL-13 ([Formula: see text] &lt; 0.0001) compared with the DSS group. Analysis of metabolic profiles of serum revealed that treatment groups were clearly separated from the DSS group, suggesting that JGT and acupuncture treatment altered serum metabolites. Furthermore, treatments caused opposite metabolite patterns for dimethylbenzimidazole, 1,5-anhydro-D-glucitol, proline, phosphate, glycolic acid, aspartic acid, tryptophan, phthalic acid, ornithine, and glutamic acid compared with the DSS group. The combined treatment group induced more effective metabolite patterns than the JGT group, implying that acupuncture treatment can restore metabolic changes caused by DSS induction. These results indicate that the simultaneous treatment of JGT administration and acupuncture procedure provides better management of the immune function and inflammatory expression of colitis than a single treatment. It is assumed that intestinal microbial control can be achieved by acupuncture stimulation as well as by taking herbal medicine. <\/jats:p>","DOI":"10.1142\/s0192415x21500464","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:48:16Z","timestamp":1617842896000},"page":"965-982","source":"Crossref","is-referenced-by-count":9,"title":["Herbal Medicine and Acupuncture Combined Treatment Attenuates Colitis in Rats"],"prefix":"10.1142","volume":"49","author":[{"given":"Yu-Mi","family":"Lee","sequence":"first","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ho","family":"Seo","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Young","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Woo","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Health Administration, Dongshin University, Naju, Jeollanam-do, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Daegu Haany University Daegu 42158, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Hwan","family":"Youn","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sok Cheon","family":"Pak","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Seok","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Food Biosciences and Technology, Korea University, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Su","family":"Na","sequence":"additional","affiliation":[{"name":"College of Korean Medicine, Dongshin University, Naju, Jeollanam-do 58245, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"S0192415X21500464BIB001","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12017"},{"key":"S0192415X21500464BIB002","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-012-9441-1"},{"key":"S0192415X21500464BIB003","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00559"},{"key":"S0192415X21500464BIB004","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv057"},{"key":"S0192415X21500464BIB005","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000479"},{"key":"S0192415X21500464BIB006","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i31.11000"},{"key":"S0192415X21500464BIB007","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2017.00021"},{"key":"S0192415X21500464BIB008","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00040-2"},{"key":"S0192415X21500464BIB009","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"S0192415X21500464BIB010","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9706140"},{"key":"S0192415X21500464BIB011","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.015"},{"key":"S0192415X21500464BIB012","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9345-1"},{"key":"S0192415X21500464BIB013","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(97)80003-9"},{"key":"S0192415X21500464BIB014","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0306-4"},{"key":"S0192415X21500464BIB015","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4810258"},{"key":"S0192415X21500464BIB016","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13414"},{"key":"S0192415X21500464BIB017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084410"},{"key":"S0192415X21500464BIB018","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064152"},{"key":"S0192415X21500464BIB019","doi-asserted-by":"publisher","DOI":"10.2174\/1874091X01004010053"},{"key":"S0192415X21500464BIB020","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/158352"},{"key":"S0192415X21500464BIB021","doi-asserted-by":"publisher","DOI":"10.1159\/000078151"},{"key":"S0192415X21500464BIB022","doi-asserted-by":"publisher","DOI":"10.1038\/nature10772"},{"key":"S0192415X21500464BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.08.350"},{"key":"S0192415X21500464BIB024","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.008"},{"key":"S0192415X21500464BIB025","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.01.019"},{"key":"S0192415X21500464BIB026","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2011.52.6.892"},{"key":"S0192415X21500464BIB027","doi-asserted-by":"publisher","DOI":"10.3839\/jabc.2017.036"},{"key":"S0192415X21500464BIB028","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010215"},{"key":"S0192415X21500464BIB029","doi-asserted-by":"publisher","DOI":"10.1093\/jcag\/gwy055"},{"key":"S0192415X21500464BIB030","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.099127"},{"key":"S0192415X21500464BIB031","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes6020017"},{"key":"S0192415X21500464BIB032","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249748"},{"key":"S0192415X21500464BIB033","first-page":"309","volume":"4","author":"Li R.","year":"2011","journal-title":"Int. J. Clin. Exp. Med."},{"key":"S0192415X21500464BIB034","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz190"},{"key":"S0192415X21500464BIB035","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0454-4"},{"key":"S0192415X21500464BIB036","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0084-8"},{"key":"S0192415X21500464BIB037","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.024"},{"key":"S0192415X21500464BIB038","first-page":"638","volume":"299","author":"Nanji A.A.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"S0192415X21500464BIB039","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260622"},{"key":"S0192415X21500464BIB040","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12464"},{"key":"S0192415X21500464BIB041","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.028"},{"key":"S0192415X21500464BIB042","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0813-5"},{"key":"S0192415X21500464BIB043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.119"},{"key":"S0192415X21500464BIB044","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.08.002"},{"key":"S0192415X21500464BIB045","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105328"},{"key":"S0192415X21500464BIB046","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-0985-1"},{"key":"S0192415X21500464BIB047","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.340"},{"key":"S0192415X21500464BIB048","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2017.11.069"},{"key":"S0192415X21500464BIB049","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9100226"},{"key":"S0192415X21500464BIB050","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4572764"},{"key":"S0192415X21500464BIB051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04515.x"},{"key":"S0192415X21500464BIB052","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163202"},{"key":"S0192415X21500464BIB053","first-page":"268","volume":"29","author":"Triantafillidis J.K.","year":"2016","journal-title":"Ann. Gastroenterol."},{"key":"S0192415X21500464BIB054","first-page":"210","volume":"28","author":"Triantafyllidi A.","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"S0192415X21500464BIB055","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4701"},{"key":"S0192415X21500464BIB056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00512.x"},{"key":"S0192415X21500464BIB057","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-015-0061-x"},{"key":"S0192415X21500464BIB058","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.03.024"},{"key":"S0192415X21500464BIB059","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i7.2195"},{"key":"S0192415X21500464BIB060","first-page":"36","volume":"3","author":"Zaslawski C.","year":"2008","journal-title":"Aust. J. Acupunct. Chin. Med."},{"key":"S0192415X21500464BIB061","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.2174\/1381612822666161208142617","volume":"23","author":"Zhao L.","year":"2017","journal-title":"Curr. Pharm. Des."}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X21500464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T08:59:00Z","timestamp":1620291540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X21500464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":61,"journal-issue":{"issue":"04","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1142\/S0192415X21500464"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x21500464","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}