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Breviscapine has a broad spectrum of pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, decreasing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation, and thrombosis formation, etc. In addition, breviscapine and its analogs have significant value for drug research and development because of the superiority of those significant bioactivities. Furthermore, an increasing number of pharmacokinetic studies have explored the mechanism of scutellarin and its analogs. To provide a comprehensive understanding of the current research on breviscapine, scutellarin, and the analogs, the structural features, distribution situation, preparation method, content determination method, clinical applications, pharmacological action as well as pharmacokinetics are summarized in the present review.<\/jats:p>","DOI":"10.1142\/s0192415x21500646","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T07:15:16Z","timestamp":1626333316000},"page":"1369-1397","source":"Crossref","is-referenced-by-count":64,"title":["Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects"],"prefix":"10.1142","volume":"49","author":[{"given":"Luan","family":"Wen","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. 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