{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:56:50Z","timestamp":1790632610032,"version":"4.1.0"},"reference-count":55,"publisher":"World Scientific Pub Co Pte Ltd","issue":"01","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202805"],"award-info":[{"award-number":["81202805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82074254"],"award-info":[{"award-number":["82074254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Natural Science Foundation","award":["7172185"],"award-info":[{"award-number":["7172185"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> The efficacy and safety of Shengmai preparation combined with Western medicine (SMP\u2013WM) to treat coronary heart disease (CHD) were reviewed. Twenty-five randomized controlled trials of SMP\u2013WM treatment for CHD were retrieved from seven databases and other trial sources between their inception and April 10, 2021. The risk of bias domains was accessed by Cochrane Collaboration\u2019s tool, and the data were statistically analyzed using RevMan 5.3 and Stata 12.0 software. The majority of included studies had a low or unclear risk of overall bias. Total mortality was not reduced (RR = 0.39, 95% CI: 0.13\u20131.19, [Formula: see text] = 0.10), but the cardiovascular events (RR = 0.35, 95% CI: 0.22\u20130.54, [Formula: see text] &lt; 0.01), weekly frequency (SMD = \u22122.38, 95% CI: \u22122.89 \u2013 \u22121.88, [Formula: see text] &lt; 0.01), and duration (SMD = \u22123.24, 95% CI: \u22123.76 \u2013 \u22122.71, [Formula: see text] &lt; 0.01) of angina pectoris attacks were significantly decreased by SMP\u2013WM. The SMP\u2013WM combination exerted antiplatelet activity by reducing platelet adhesion (SMD = \u22120.97, 95% CI: \u22121.49 \u2013 \u22120.45, [Formula: see text] = 0.0003) and the platelet reactivity index (SMD = \u22121.75, 95% CI: \u22122.04 \u2013 \u22121.46, [Formula: see text] &lt; 0.01). SMP\u2013WM could protect endothelial function by increasing nitric oxide (SMD = 1.28, 95% CI: 0.54\u20132.02, [Formula: see text] &lt; 0.01) and decreasing endothelin (SMD = \u22121.26, 95% CI: \u22121.85 \u2013 \u22120.66, [Formula: see text] &lt; 0.01). The combination also improved hemorheology by reducing whole blood viscosity (SMD = \u22121.59, 95% CI: \u22122.32 \u2013 \u22120.85, [Formula: see text] &lt; 0.01), plasma viscosity (SMD = \u22120.65, 95% CI: \u22120.86 \u2013 \u22120.45, [Formula: see text] &lt; 0.01), and fibrinogen (SMD = \u22124.21, 95% CI: \u22124.58 \u2013 \u22123.83, [Formula: see text] &lt; 0.01). The SMP\u2013WM combination favorably impacts cardiovascular events, angina symptoms, endothelial function, platelet aggregation, and blood viscosity, with comparable safety to that of routine Western medicine. Further investigation is required to enhance the strength of the evidence. <\/jats:p>","DOI":"10.1142\/s0192415x22500057","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T11:41:03Z","timestamp":1640086863000},"page":"133-159","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Safety of Shengmai Preparation Combined with Western Medicine for Coronary Heart Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1142","volume":"50","author":[{"given":"Yujuan","family":"Li","sequence":"first","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Guang\u2019an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"S0192415X22500057BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.01.015"},{"key":"S0192415X22500057BIB002","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079418"},{"key":"S0192415X22500057BIB004","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180973"},{"key":"S0192415X22500057BIB005","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2018.1523933"},{"key":"S0192415X22500057BIB006","first-page":"164","volume":"19","author":"Dai L.H.","year":"2019","journal-title":"World Latest Med. Inf. (Elect. Vers.)"},{"key":"S0192415X22500057BIB007","first-page":"129","volume":"23","author":"Ding Y.B.","year":"2008","journal-title":"Chin. Commun. Doctors"},{"key":"S0192415X22500057BIB008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"S0192415X22500057BIB009","doi-asserted-by":"publisher","DOI":"10.3310\/hta7010"},{"key":"S0192415X22500057BIB010","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs411"},{"key":"S0192415X22500057BIB011","first-page":"116","volume":"2","author":"Fan X.F.","year":"2010","journal-title":"J. China Tradit. Chin. Med. Inf."},{"key":"S0192415X22500057BIB012","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7016.1356"},{"key":"S0192415X22500057BIB013","first-page":"939","volume":"36","author":"Gu Y.M.","year":"2009","journal-title":"Liaoning J. Tradit. Chin. Med."},{"key":"S0192415X22500057BIB014","first-page":"6","volume":"41","author":"Guo W.J.","year":"2012","journal-title":"J. Zhejiang Univ. Med. Sci."},{"key":"S0192415X22500057BIB015","first-page":"108","volume":"20","author":"Han B.","year":"2019","journal-title":"Clin. Med."},{"key":"S0192415X22500057BIB016","first-page":"23","volume":"21","author":"He J.R.","year":"2000","journal-title":"Shanghai Med. Pharm. J."},{"key":"S0192415X22500057BIB017","first-page":"188","volume":"11","author":"He Y.Z.","year":"2002","journal-title":"J. Emerg. Tradit. Chin. Med."},{"key":"S0192415X22500057BIB018","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.2.","author":"Higgins J.P.T.","year":"2021"},{"key":"S0192415X22500057BIB019","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0.","author":"Higgins J.P.T.","year":"2011"},{"key":"S0192415X22500057BIB020","first-page":"554","volume":"36","author":"Huang Y.H.","year":"2015","journal-title":"Shanxi J. Tradit. Chin. Med."},{"key":"S0192415X22500057BIB021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2019.05.005"},{"key":"S0192415X22500057BIB022","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"S0192415X22500057BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.02.001"},{"key":"S0192415X22500057BIB024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2016.11.003"},{"key":"S0192415X22500057BIB025","first-page":"215","volume":"4","author":"Jiao J.","year":"2016","journal-title":"Chin. J. Heart Rhython (Elect. Ed.)"},{"key":"S0192415X22500057BIB026","first-page":"333","volume":"28","author":"Li X.M.","year":"2006","journal-title":"J. Shandong Med. Coll."},{"key":"S0192415X22500057BIB027","first-page":"69","volume":"10","author":"Liang Z.Z.","year":"2013","journal-title":"Chin. Med. Herald"},{"key":"S0192415X22500057BIB028","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X20500172"},{"key":"S0192415X22500057BIB029","first-page":"32","volume":"6","author":"Lu J.M.","year":"2011","journal-title":"Nat. Med. Front. China"},{"key":"S0192415X22500057BIB030","first-page":"318","volume":"16","author":"Ma E.L.","year":"2001","journal-title":"West China J. Pharm. Sci."},{"key":"S0192415X22500057BIB032","first-page":"2002","volume":"23","author":"Meng X.W.","year":"2014","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"S0192415X22500057BIB033","first-page":"1549","volume":"23","author":"Meng X.W.","year":"2014","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"S0192415X22500057BIB034","first-page":"1430","volume":"40","author":"National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine and Chinese Medical Association Branch of Integrated Traditional Chinese and Western Medicine","year":"2020","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"S0192415X22500057BIB035","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X20500147"},{"key":"S0192415X22500057BIB036","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"S0192415X22500057BIB037","first-page":"1851","volume":"20","author":"Pan C.H.","year":"2011","journal-title":"J. Emerg. Tradit. Chin. Med."},{"key":"S0192415X22500057BIB038","doi-asserted-by":"publisher","DOI":"10.1080\/17476930500454514"},{"key":"S0192415X22500057BIB039","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"S0192415X22500057BIB040","first-page":"1042","volume":"33","author":"Shen Z.F.","year":"2018","journal-title":"Drugs Clin."},{"key":"S0192415X22500057BIB041","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-010-0864-9"},{"key":"S0192415X22500057BIB042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.11.003"},{"key":"S0192415X22500057BIB043","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6921.72"},{"key":"S0192415X22500057BIB044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw334"},{"key":"S0192415X22500057BIB045","first-page":"193","volume":"30","author":"Wang Z.","year":"2017","journal-title":"J. Med. Theory Pract."},{"key":"S0192415X22500057BIB046","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5246\/jcps.2020.02.012","volume":"29","author":"Wang Z.L.","year":"2020","journal-title":"China Pharmacol."},{"key":"S0192415X22500057BIB047","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.03.024"},{"key":"S0192415X22500057BIB048","doi-asserted-by":"publisher","DOI":"10.5888\/pcd13.160211"},{"key":"S0192415X22500057BIB049","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2018.0516"},{"key":"S0192415X22500057BIB050","first-page":"394","volume":"21","author":"Xin S.M.","year":"1999","journal-title":"J. Youjiang Med. Coll. Nat."},{"key":"S0192415X22500057BIB051","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.12.016"},{"key":"S0192415X22500057BIB052","first-page":"149","volume":"6","author":"Zhang X.","year":"2018","journal-title":"Cardiovasc. Dis. J. Integr. Tradit. Chin. West. Med."},{"key":"S0192415X22500057BIB053","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-008-0107-3"},{"key":"S0192415X22500057BIB054","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-008-0281-3"},{"key":"S0192415X22500057BIB055","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"},{"key":"S0192415X22500057BIB056","first-page":"CD005052","volume":"4","author":"Zhou Q.","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"S0192415X22500057BIB057","first-page":"14","volume":"47","author":"Zou Y.","year":"2015","journal-title":"J. New Chin. Med."}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X22500057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T02:11:05Z","timestamp":1645495865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0192415X22500057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,20]]},"references-count":55,"journal-issue":{"issue":"01","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1142\/S0192415X22500057"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x22500057","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,20]]}}}