{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:24:36Z","timestamp":1787495076553,"version":"build-2736575974"},"reference-count":48,"publisher":"World Scientific Pub Co Pte Ltd","issue":"05","funder":[{"name":"Ditmanson Medical Foundation Chiayi Christian Hospital","award":["I108HH132"],"award-info":[{"award-number":["I108HH132"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["MOST-1 09-2635-B-468-0013"],"award-info":[{"award-number":["MOST-1 09-2635-B-468-0013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Cisplatin is massively used to treat solid tumors. However, several severe adverse effects, such as cardiotoxicity, are obstacles to its clinical application. Cardiotoxicity may lead to congestive heart failure and even sudden cardiac death in patients receiving cisplatin. Therefore, finding a novel therapeutic strategy for the prevention of cisplatin-induced cardiotoxicity is urgent. Quercetin is a flavonol compound that can be found in dietary fruits and vegetables. The antioxidant function and anti-inflammatory capacity of quercetin have been reported. However, whether quercetin could protect against cisplatin-caused apoptosis and cellular damage in cardiomyocytes is still unclear. H9c2 cardiomyocytes were treated with cisplatin (40 \u03bcM) for 24 h to induce cellular damage with or without quercetin pretreatment. We found that quercetin activates Nrf2 and HO-1 expression, thereby mitigating cisplatin-caused cytotoxicity in H9c2 cells. Quercetin also increases SOD levels, maintains mitochondrial function, and reduces oxidative stress under cisplatin stimulation. Quercetin attenuates cisplatin-induced apoptosis and inflammation in H9c2 cardiomyocytes; however, these cytoprotective effects were diminished by silencing Nrf2 and HO-1. In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2\/HO-1 and p38MAPK\/NF-[Formula: see text]Bp65\/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.<\/jats:p>","DOI":"10.1142\/s0192415x22500537","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T03:26:32Z","timestamp":1654572392000},"page":"1281-1298","source":"Crossref","is-referenced-by-count":67,"title":["Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2\/HO-1 Signaling Pathway"],"prefix":"10.1142","volume":"50","author":[{"given":"Shih-Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Ditmanson Medical Foundation, Chiayi Christian Hospital, Chiayi, Taiwan"},{"name":"Department of Audiology and Speech-Language Pathology, College of Medical and Health Science, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ling","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ching","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Chung","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medical and Health Science, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ching","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"key":"S0192415X22500537BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2014.12.008"},{"key":"S0192415X22500537BIB002","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2018-0080"},{"key":"S0192415X22500537BIB003","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq004"},{"key":"S0192415X22500537BIB004","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.12.008"},{"key":"S0192415X22500537BIB005","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117584"},{"key":"S0192415X22500537BIB006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"S0192415X22500537BIB007","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2016.10.001"},{"key":"S0192415X22500537BIB008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.085"},{"key":"S0192415X22500537BIB009","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00279"},{"key":"S0192415X22500537BIB010","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2019.5902"},{"key":"S0192415X22500537BIB011","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/104308"},{"key":"S0192415X22500537BIB012","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22624"},{"key":"S0192415X22500537BIB013","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuz071"},{"key":"S0192415X22500537BIB014","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.01.022"},{"key":"S0192415X22500537BIB015","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21977"},{"key":"S0192415X22500537BIB016","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/725174"},{"key":"S0192415X22500537BIB017","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-021-09636-3"},{"key":"S0192415X22500537BIB018","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-012-0719-0"},{"key":"S0192415X22500537BIB019","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090016"},{"key":"S0192415X22500537BIB020","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226769"},{"key":"S0192415X22500537BIB021","first-page":"3098","volume":"5","author":"Li Z.","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"S0192415X22500537BIB022","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00434"},{"key":"S0192415X22500537BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105575"},{"key":"S0192415X22500537BIB024","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5619"},{"key":"S0192415X22500537BIB025","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.046"},{"key":"S0192415X22500537BIB026","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.10.819"},{"key":"S0192415X22500537BIB027","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1773864"},{"key":"S0192415X22500537BIB028","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.238"},{"key":"S0192415X22500537BIB029","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.06.053"},{"key":"S0192415X22500537BIB030","first-page":"1959","volume":"15","author":"Qian P.","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"S0192415X22500537BIB031","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133177"},{"key":"S0192415X22500537BIB032","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.06.038"},{"key":"S0192415X22500537BIB033","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr195"},{"key":"S0192415X22500537BIB034","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2021-0008"},{"key":"S0192415X22500537BIB035","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S228361"},{"key":"S0192415X22500537BIB036","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54065-6"},{"key":"S0192415X22500537BIB037","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3278"},{"key":"S0192415X22500537BIB038","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9703609"},{"key":"S0192415X22500537BIB039","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-007-0063-0"},{"key":"S0192415X22500537BIB040","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S267383"},{"key":"S0192415X22500537BIB041","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-013-2260-4"},{"key":"S0192415X22500537BIB042","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2934"},{"key":"S0192415X22500537BIB043","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00191F"},{"key":"S0192415X22500537BIB044","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14371"},{"key":"S0192415X22500537BIB045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.02.008"},{"key":"S0192415X22500537BIB046","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01253"},{"key":"S0192415X22500537BIB047","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2015.0037"},{"key":"S0192415X22500537BIB048","first-page":"232","volume":"22","author":"Zhao L.","year":"2019","journal-title":"Anatol. J. Cardiol."}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X22500537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T05:09:24Z","timestamp":1660194564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S0192415X22500537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":48,"journal-issue":{"issue":"05","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1142\/S0192415X22500537"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x22500537","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}