{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:10:31Z","timestamp":1773076231252,"version":"3.50.1"},"reference-count":51,"publisher":"World Scientific Pub Co Pte Ltd","issue":"05","funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"crossref","award":["TSGH-D-110073"],"award-info":[{"award-number":["TSGH-D-110073"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science and Technology","award":["MOST 110-2314-B-303-006"],"award-info":[{"award-number":["MOST 110-2314-B-303-006"]}]},{"name":"Ministry of Science and Technology","award":["MOST 106-2320-B-303-004-MY3"],"award-info":[{"award-number":["MOST 106-2320-B-303-004-MY3"]}]},{"DOI":"10.13039\/501100022298","name":"Hualien Tzu Chi Hospital","doi-asserted-by":"crossref","award":["TCRD110-80"],"award-info":[{"award-number":["TCRD110-80"]}],"id":[{"id":"10.13039\/501100022298","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China Medical University and Asia University","award":["CMU106-ASIA-02"],"award-info":[{"award-number":["CMU106-ASIA-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Neurodegenerative diseases have become increasingly prevalent in the aged population. Rheumatoid arthritis (RA) is an autoimmune disease that causes systemic inflammation, damaging the neurons. However, only a few treatment options can reduce RA-induced neurodegeneration. This study aimed to evaluate whether adipose-derived stem cells (ADSCs) pretreated with curcumin could ameliorate RA-induced neurodegenerative illness in an RA rat model. Wistar rats were randomly classified into the following four groups: control, RA, RA + ADSC (1 \u00d7 10<jats:sup>6<\/jats:sup> cells per rat), and RA + curcumin-pretreated ADSC (1 \u00d7 10<jats:sup>6<\/jats:sup> cells per rat). After treatment for two months, the effects were specifically evaluated in the brains collected from the rats. Our results demonstrated that the transplantation of curcumin-pretreated ADSCs substantially reduced inflammation and apoptosis in the cortices of RA rats compared to those of other groups. Thus, the combination of ADSCs and curcumin exerts a synergistic effect in enhancing neuronal protection in RA rats. In the future, this combination therapeutic strategy can potentially be used as a novel treatment method to reduce RA-induced neurodegenerative disorders. <\/jats:p>","DOI":"10.1142\/s0192415x22500549","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:24:36Z","timestamp":1655785476000},"page":"1299-1314","source":"Crossref","is-referenced-by-count":14,"title":["Curcumin-Pretreated Adipose-Derived Stem Cells Enhance the Neuroprotective Ability to Repair Rheumatoid Arthritis-Induced Damage in the Rat Brain"],"prefix":"10.1142","volume":"50","author":[{"given":"Da-Tong","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce Chi-Kang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angelina","family":"Sitorus","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, China Medical University, Taichung, Taiwan"},{"name":"Ph.D. Program for Biotechnology Industry, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hua","family":"Kuo","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Science, National Taiwan Normal University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis Jine-Yuan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan"},{"name":"Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Jung","family":"Ho","sequence":"additional","affiliation":[{"name":"Integration Center of Traditional Chinese and Modern Medicine, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"},{"name":"Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"},{"name":"School of Post-Baccalaureate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"},{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan"},{"name":"Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan"},{"name":"School of Post-Baccalaureate Chinese Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"S0192415X22500549BIB001","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_1"},{"key":"S0192415X22500549BIB002","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810553115"},{"key":"S0192415X22500549BIB003","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23145"},{"key":"S0192415X22500549BIB004","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031185"},{"key":"S0192415X22500549BIB005","doi-asserted-by":"publisher","DOI":"10.1186\/ar3065"},{"key":"S0192415X22500549BIB006","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13666"},{"key":"S0192415X22500549BIB007","doi-asserted-by":"publisher","DOI":"10.37796\/2211-8039.1191"},{"key":"S0192415X22500549BIB008","first-page":"44","volume":"87","author":"Chattopadhyay I.","year":"2004","journal-title":"Curr. 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