{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:45:06Z","timestamp":1792799106414,"version":"4.5.0"},"reference-count":45,"publisher":"World Scientific Pub Co Pte Ltd","issue":"01","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070419"],"award-info":[{"award-number":["82070419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the 2020 Key Scientific and Technological Project for Medical Devices from the Science and Technology Commission of Shanghai Municipality","award":["20S31901900"],"award-info":[{"award-number":["20S31901900"]}],"id":[{"id":"https:\/\/ror.org\/03kt66j61","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Isoproterenol (ISO) is widely used to treat bronchial asthma, cardiogenic or septic shock, complete atrioventricular block, and cardiac arrest. However, it can also cause myocardial damage owing to infarct-like necrosis. Curdione, an extract of the Chinese herb Rhizoma Curcumae, has a variety of pharmacological activities, including cardioprotective effects. In this study, we investigated the protective effects of curdione and its underlying mechanisms in an ISO-induced myocardial injury model. Our results showed that curdione attenuated ISO-induced H9c2 cell proliferation inhibition and lactic dehydrogenase (LDH) release. Curdione ameliorated morphological damage and reduced the ISO-induced elevation of serum creatine kinase-MB isoenzyme (CK-MB) and LDH.\u00a0Furthermore, curdione inhibited ISO-induced cell apoptosis, modulated the expression of Bcl-2 and Bax proteins, repealed the accumulation of ISO-induced reactive oxygen species (ROS), prevented mitochondrial dysfunction, and activated the Nrf2\/SOD1\/HO-1 signaling pathway. The above results show that curdione exerts a protective effect against ISO-induced myocardial damage by inhibiting apoptosis and oxidative stress, suggesting that curdione is a potential therapeutic strategy to prevent ISO-induced myocardial damage.<\/jats:p>","DOI":"10.1142\/s0192415x23500052","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T11:55:41Z","timestamp":1670327741000},"page":"73-89","source":"Crossref","is-referenced-by-count":16,"title":["Curdione Relieved Isoproterenol-Induced Myocardial Damage through Inhibiting Oxidative Stress and Apoptosis"],"prefix":"10.1142","volume":"51","author":[{"given":"Yulei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovasology, Shanghai Changhai Hospital, Shanghai 200433, P.\u00a0R.\u00a0China"},{"name":"Department of Cardiology, Baicheng People\u2019s Hospital, Akesu City, Xinjiang 842300, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.\u00a0R.\u00a0China"},{"name":"Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai 200040, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovasology, Shanghai Changhai Hospital, Shanghai 200433, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.\u00a0R.\u00a0China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"S0192415X23500052BIB001","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200838"},{"key":"S0192415X23500052BIB002","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6152"},{"key":"S0192415X23500052BIB003","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"S0192415X23500052BIB004","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.65.3.657","volume":"65","author":"Benjamin I.J.","year":"1989","journal-title":"Circ. 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