{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:30:09Z","timestamp":1775028609309,"version":"3.50.1"},"reference-count":45,"publisher":"World Scientific Pub Co Pte Ltd","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Colorectal cancer (CRC) is a leading cause of cancer-related death in the United States, and chronic gut inflammation is a risk factor for CRC initiation and development. Curcuma longa L., or turmeric, has become one of the most studied herbal medicines in recent years due to its anticancer potentials. It is generally accepted that the major component in turmeric is curcuminoids, and the active constituent in curcuminoids is curcumin. However, unprocessed curcumin is characterized by poor water solubility, which means low bioavailability in humans. To increase the bioavailability of curcumin, in this study, we utilized a novel surfactant-formulated curcumin (CuminUP60[Formula: see text]) and evaluated its CRC chemopreventive activities. Compared with the chemo-sensitive CRC cell line HCT-116, the management of the CRC SW-480 cell line is a challenge, since the latter is chemo-resistant. In other words, these cancer cells resist the effects of the chemotherapy. Using the newly formulated CuminUP60[Formula: see text] water solution, this study demonstrated its strong antiproliferative effects on the SW-480 cells in a dose- and time-dependent manner. This new formulation induced early apoptosis and arrested the cell cycle in the G2\/M phase via the upregulation of cyclin B1. We also observed that this new formulation possessed inhibitory effects on Th17 cell differentiation, which regulates the body\u2019s immune response against gut malignancies. In summary, our results exhibited a potential clinical utility of the surfactant-formulated curcumin in chemo-resistant colorectal cancer management. <\/jats:p>","DOI":"10.1142\/s0192415x23500714","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T08:53:36Z","timestamp":1689756816000},"page":"1577-1594","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Curcuminoids and Surfactant-Formulated Curcumin on Chemo-Resistant Colorectal Cancer"],"prefix":"10.1142","volume":"51","author":[{"given":"Chunping","family":"Wan","sequence":"first","affiliation":[{"name":"Central Laboratory, No. 1, Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, P.\u00a0R.\u00a0China"},{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinge","family":"Ma","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"},{"name":"Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P.\u00a0R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Anderson","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P.\u00a0R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.\u00a0R.\u00a0China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Bell","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifei","family":"Hou","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Medicine, Boston Children\u2019s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Su","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"S0192415X23500714BIB001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","volume":"57","author":"Ammon H.P.","year":"1991","journal-title":"Planta Med."},{"key":"S0192415X23500714BIB002","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2174\/1389201021666200305115101","volume":"21","author":"Ashrafizadeh M.","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"S0192415X23500714BIB003","first-page":"1267","volume":"15","author":"Bernstein B.J.","year":"2001","journal-title":"Oncology (Williston Park)"},{"key":"S0192415X23500714BIB004","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.3390\/ijms222011024","volume":"22","author":"Briata I.M.","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"S0192415X23500714BIB005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10620-019-05754-9","volume":"65","author":"Burke K.E.","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"S0192415X23500714BIB006","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1038\/s41395-018-0354-7","volume":"113","author":"Bye W.A.","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"S0192415X23500714BIB007","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/cr900019j","volume":"109","author":"Cragg G.M.","year":"2009","journal-title":"Chem. Rev."},{"key":"S0192415X23500714BIB008","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJMoa033025","volume":"351","author":"Cunningham D.","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"S0192415X23500714BIB009","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1471-4892(01)00063-7","volume":"1","author":"da Rocha A.B.","year":"2001","journal-title":"Curr. Opin. Pharmacol."},{"key":"S0192415X23500714BIB010","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/jp411686d","volume":"118","author":"Erez Y.","year":"2014","journal-title":"J. Phys. Chem. A"},{"key":"S0192415X23500714BIB011","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1470-2045(00)00031-0","volume":"1","author":"Ernst E.","year":"2000","journal-title":"Lancet Oncol."},{"key":"S0192415X23500714BIB012","doi-asserted-by":"crossref","first-page":"e006561","DOI":"10.1136\/jitc-2022-006561","volume":"11","author":"Fakih M.","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"S0192415X23500714BIB013","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500768"},{"key":"S0192415X23500714BIB014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1200\/JCO.2004.09.046","volume":"22","author":"Goldberg R.M.","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"S0192415X23500714BIB015","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1021\/acsomega.2c07326","volume":"8","author":"Hegde M.","year":"2023","journal-title":"ACS Omega"},{"key":"S0192415X23500714BIB016","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","volume":"350","author":"Hurwitz H.","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"S0192415X23500714BIB017","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500549"},{"key":"S0192415X23500714BIB018","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3390\/cells11081326","volume":"11","author":"Khan A.W.","year":"2022","journal-title":"Cells"},{"key":"S0192415X23500714BIB019","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500860"},{"key":"S0192415X23500714BIB020","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrc723","volume":"2","author":"Mann J.","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"S0192415X23500714BIB021","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrc3469","volume":"13","author":"McCarthy N.","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"S0192415X23500714BIB022","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1523-5394.2002.103004.x","volume":"10","author":"Ott M.J.","year":"2002","journal-title":"Cancer Pract."},{"key":"S0192415X23500714BIB023","doi-asserted-by":"crossref","first-page":"994","DOI":"10.3390\/cancers3010994","volume":"3","author":"Ozaki T.","year":"2011","journal-title":"Cancers (Basel)"},{"key":"S0192415X23500714BIB024","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500956"},{"key":"S0192415X23500714BIB025","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500841"},{"key":"S0192415X23500714BIB026","first-page":"645","volume-title":"A Textbook of Complementary and Alternative Medicine","author":"Sampson W.","year":"2006"},{"key":"S0192415X23500714BIB027","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/MCO.0000000000000227","volume":"18","author":"Schaffer M.","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"S0192415X23500714BIB028","doi-asserted-by":"crossref","first-page":"e202200535","DOI":"10.1002\/cbdv.202200535","volume":"19","author":"Shaik B.B.","year":"2022","journal-title":"Chem. Biodivers."},{"key":"S0192415X23500714BIB029","doi-asserted-by":"crossref","first-page":"01021","DOI":"10.3389\/fphar.2020.01021","volume":"11","author":"Sharifi-Rad J.","year":"2020","journal-title":"Front. Pharmacol."},{"key":"S0192415X23500714BIB030","first-page":"1067","volume":"50","author":"Shumay D.M.","year":"2001","journal-title":"J. Fam. Pract."},{"key":"S0192415X23500714BIB031","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"Siegel R.L.","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"S0192415X23500714BIB032","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10552-014-0344-z","volume":"25","author":"Sineshaw H.M.","year":"2014","journal-title":"Cancer Causes Control"},{"issue":"4","key":"S0192415X23500714BIB033","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/bju.13361","volume":"117","author":"van Die M.D.","year":"2016","journal-title":"BJU Int."},{"key":"S0192415X23500714BIB034","doi-asserted-by":"crossref","first-page":"120043","DOI":"10.1016\/j.lfs.2021.120043","volume":"286","author":"Villegas C.","year":"2021","journal-title":"Life Sci."},{"key":"S0192415X23500714BIB035","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1158\/1535-7163.MCT-05-0212","volume":"5","author":"Voland C.","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"S0192415X23500714BIB036","first-page":"2021a","volume":"72","author":"Wang C.Z.","journal-title":"J. Physiol. Pharmacol."},{"key":"S0192415X23500714BIB037","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500100"},{"key":"S0192415X23500714BIB038","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500270"},{"key":"S0192415X23500714BIB039","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500434"},{"key":"S0192415X23500714BIB040","first-page":"22","volume":"59","author":"Wu R.","year":"2020","journal-title":"Mol. Carcinog."},{"key":"S0192415X23500714BIB041","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X2150049X"},{"key":"S0192415X23500714BIB042","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500604"},{"key":"S0192415X23500714BIB043","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/ijo.2013.1946","volume":"43","author":"Zhang Z.","year":"2013","journal-title":"Int. J. Oncol."},{"key":"S0192415X23500714BIB044","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500385"},{"key":"S0192415X23500714BIB045","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500877"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X23500714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T07:18:44Z","timestamp":1693466324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S0192415X23500714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":45,"journal-issue":{"issue":"06","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1142\/S0192415X23500714"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x23500714","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}