{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:53:00Z","timestamp":1782769980782,"version":"3.54.5"},"reference-count":45,"publisher":"World Scientific Pub Co Pte Ltd","issue":"07","funder":[{"name":"the Chia-Yi Christian Hospital and the Asia University, Taiwan","award":["10933007"],"award-info":[{"award-number":["10933007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Hypertrophic cardiomyopathy accompanies numerous cardiovascular diseases, and the intervention of cardiac hypertrophy is an important issue to prevent detrimental consequences. Mangiferin (MGN) is a glucosylxanthone found in Mangifera indica, which exhibits anti-oxidant and anti-inflammatory properties. Various studies have demonstrated the cardioprotective potential of MGN, but the mechanisms behind its beneficial effects have not been fully revealed. Here, angiotensin-II (Ang-II) was used to induce cardiac hypertrophy, and we examined cell size, expression of hypertrophy markers (e.g., ANP, BNP, and [Formula: see text]-MHC), and oxidative stress (e.g., the ratio of NADPH\/NADP[Formula: see text], the expression of p22phox and p67phox, and ROS and SOD production) of cardiomyocytes. Moreover, we assessed the activation of mitogen-activated protein kinase (MAPK) signaling (e.g., p38 and ERK) and the NF-[Formula: see text]Bp65\/iNOS axis. Additionally, an annexin V\/PI assay was employed to evaluate whether MGN administration can attenuate Ang-II-elicited apoptosis. Lastly, the expression of Ang-II type 1 receptor (AT1) was measured to confirm its involvement in MGN-mediated protection. Our results showed that treatment with MGN attenuated the Ang-II-induced cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes. MGN also abrogated the activation of MAPK signaling and the NF-[Formula: see text]Bp65\/iNOS axis. Additionally, MGN prevented apoptosis and downregulated the elevation of AT1 in cardiomyocytes that had been exposed to Ang-II. Altogether, these results demonstrated the potential of using MGN to ameliorate the Ang-II-associated cardiac hypertrophy, which may be due to its anti-oxidant and anti-inflammatory effects through suppression of MAPK signaling and the NF-[Formula: see text]Bp65\/iNOS axis. <\/jats:p>","DOI":"10.1142\/s0192415x23500829","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:56:21Z","timestamp":1692885381000},"page":"1865-1878","source":"Crossref","is-referenced-by-count":2,"title":["Mangiferin Protects against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes"],"prefix":"10.1142","volume":"51","author":[{"given":"Chih-Chia","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Radiation Therapy and Oncology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan"},{"name":"Department of Medical Laboratory and Biotechnology, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ling","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"},{"name":"Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ching","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ling","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Da","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Asia University, Taichung, Taiwan"},{"name":"Department of Physical Therapy, Ph.D. Program in Healthcare Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"S0192415X23500829BIB001","first-page":"e26642","volume":"14","author":"Akhtar H.","year":"2022","journal-title":"Cureus"},{"key":"S0192415X23500829BIB002","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/cells11213336","volume":"11","author":"Bhullar S.K.","year":"2022","journal-title":"Cells"},{"key":"S0192415X23500829BIB003","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.18632\/aging.102956","volume":"12","author":"Chen Y.","year":"2020","journal-title":"Aging"},{"key":"S0192415X23500829BIB004","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/excr.1997.3477","volume":"231","author":"Cigola E.","year":"1997","journal-title":"Exp. 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