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In this study, models of rat myocardial I\/R injury and hypoxia\/reoxygenation (H\/R)-induced cardiomyocyte injury were generated. The infarct size, histological changes and apoptosis in heart tissues were evaluated by TTC, HE, and TUNEL staining. CCK-8, flow cytometry and immunofluorescence were employed to assess cell viability, apoptosis and autophagosome\u2013lysosome fusion in H9c2 cells. The associations among SNHG5, LIN28A and BCAT1 mRNA were detected by RNA pull-down, RIP, and RNA fluorescence in situ hybridization (FISH) assays. Western Blot, qRT-PCR and immunohistochemistry were employed to detect the expression of key molecules. Our results revealed that Dex ameliorated myocardial I\/R injury and H\/R-induced impairments in H9c2 cells by enhancing autophagy. Moreover, Dex led to a rebound of SNHG5 in the heart tissues of I\/R rats and H\/R-treated H9c2 cells, and functional studies revealed that Dex protected against cardiac impairments through SNHG5-dependent autophagy in vitro and in vivo. Furthermore, SNHG5 alleviated H\/R-induced impairments by recruiting LIN28A protein, which was subsequently bound to BCAT1 mRNA and maintained its stability. In conclusion, our findings demonstrated that SNHG5, when upregulated by Dex, alleviated myocardial I\/R injury through LIN28A-mediated BCAT1 mRNA stabilization and autophagy enhancement. <\/jats:p>","DOI":"10.1142\/s0192415x25500442","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T03:23:29Z","timestamp":1752290609000},"page":"1593-1614","source":"Crossref","is-referenced-by-count":1,"title":["SNHG5 Upregulated by Dexmedetomidine Alleviates Myocardial Ischemia\/Reperfusion Injury Through LIN28A-Mediated BCAT1 mRNA Stabilization and Autophagy Enhancement"],"prefix":"10.1142","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7041-9738","authenticated-orcid":false,"given":"Jingjia","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-5696","authenticated-orcid":false,"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0086-025X","authenticated-orcid":false,"given":"Wenzhi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5861-2603","authenticated-orcid":false,"given":"Xu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"219","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"S0192415X25500442BIB001","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.01.022"},{"key":"S0192415X25500442BIB002","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006487"},{"key":"S0192415X25500442BIB003","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8118"},{"key":"S0192415X25500442BIB004","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500641"},{"key":"S0192415X25500442BIB005","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.118703"},{"key":"S0192415X25500442BIB006","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030583"},{"key":"S0192415X25500442BIB007","doi-asserted-by":"publisher","DOI":"10.1261\/rna.036491.112"},{"key":"S0192415X25500442BIB008","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603783200"},{"key":"S0192415X25500442BIB009","first-page":"5183","volume":"20","author":"Han H.","year":"2019","journal-title":"Mol. 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