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The typical manifestations of MI include persistent substernal chest pain, dyspnea, nausea, vomiting, and diaphoresis. Astragaloside IV (AS-IV), a major bioactive component of Astragalus membranaceus, has been extensively investigated over the past decade. Evidence indicates that AS-IV exerts multifaceted protective effects against MI by modulating various key signaling pathways involved in anti-inflammatory, anti-oxidative stress, and antifibrotic activities, the inhibition of cardiomyocyte apoptosis, and the maintenance of mitochondrial homeostasis. These pathways include TLR4\/NF-\u03baB, PI3K\/AKT, TGF-\u03b2\/Smad2, ROS\/caspase-1\/GSDMD, Wnt\/\u03b2-catenin, AMPK\/ACSS2\/PPAR\u03b1, Sirt3\/Drp1, and PINK1\/Parkin. Although mechanistic studies have substantially advanced, the clinical application of AS-IV in MI remains in the exploratory stage. Further well-designed clinical trials are necessary in order to validate the therapeutic efficacy and safety of AS-IV, thereby facilitating its translation from experimental research to clinical practice, and offering new insights and potential strategies for MI management.<\/jats:p>","DOI":"10.1142\/s0192415x26500205","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:46:31Z","timestamp":1771213591000},"page":"555-572","source":"Crossref","is-referenced-by-count":1,"title":["Research Progress on the Mechanism of Astragaloside IV for Treating Myocardial Infarction"],"prefix":"10.1142","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4747-1292","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-6219","authenticated-orcid":false,"given":"Yijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0258-3986","authenticated-orcid":false,"given":"Guiping","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Engineering Medicine, Beihang University, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5656-2703","authenticated-orcid":false,"given":"Ming","family":"Ren","sequence":"additional","affiliation":[{"name":"Baokang Hospital, Affiliated with the Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-9324","authenticated-orcid":false,"given":"Yanguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2572-9445","authenticated-orcid":false,"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-6256","authenticated-orcid":false,"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7464-0470","authenticated-orcid":false,"given":"Weihong","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3146-8869","authenticated-orcid":false,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"},{"name":"State Key Laboratory of Chinese Medicine Modernization, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"S0192415X26500205BIB001","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.683151"},{"key":"S0192415X26500205BIB002","first-page":"27","volume":"31","author":"Cao Q.D.","year":"2015","journal-title":"Pharm. 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