{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:02:10Z","timestamp":1784606530333,"version":"3.55.0"},"reference-count":54,"publisher":"World Scientific Pub Co Pte Ltd","issue":"05","funder":[{"name":"Anhui Provincial Department of Education Scientific Research Project","award":["2025AHGXZK40547"],"award-info":[{"award-number":["2025AHGXZK40547"]}]},{"name":"Regional Innovation and Development Joint Fund of the NSFC","award":["U22A20366"],"award-info":[{"award-number":["U22A20366"]}]},{"name":"Anhui Province Traditional Chinese Medicine Science and Technology Research Special Project","award":["202303a07020004"],"award-info":[{"award-number":["202303a07020004"]}]},{"name":"Anhui Province Clinical Medical Research Translation Special Programme","award":["202204295107020066"],"award-info":[{"award-number":["202204295107020066"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82505546"],"award-info":[{"award-number":["82505546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Anhui Provincial Natural Science Foundation","award":["2408085QH283"],"award-info":[{"award-number":["2408085QH283"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am. J. Chin. Med."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, plays a critical role in various diseases. Berberine, a bioactive compound from plants such as Coptis chinensis, tree turmeric, and barberry, exhibits bidirectional regulation of ferroptosis, but its systemic mechanisms remain unclear. This review summarizes berberine\u2019s effects through multiple signaling pathways, emphasizing context-dependent mechanisms, tissue-specific accumulation, and therapeutic potential. Relevant literature was retrieved from PubMed, Web of Science, CNKI, and ScienceDirect. Berberine modulates ferroptosis via iron homeostasis, lipid peroxidation, the System Xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/GSH\/GPX4 anti-oxidant system, and mitochondrial function, involving NRF2, p53, AMPK, PI3K\/Akt, and MAPK pathways. It promotes ferroptosis in tumors and fibrotic diseases but inhibits it in cardiovascular, metabolic, and neurological disorders, alleviating tissue damage. Nano-delivery systems and structural optimization enhance bioavailability and targeting, demonstrating therapeutic efficacy and biosafety. Berberine\u2019s multi-target, bidirectional regulation shows promising clinical potential, warranting further mechanistic and delivery-focused studies.\n                  <\/jats:p>","DOI":"10.1142\/s0192415x26500540","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:26:32Z","timestamp":1783416392000},"page":"1475-1497","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Ferroptosis: Effects and Mechanisms of Action of Berberine"],"prefix":"10.1142","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0779-4272","authenticated-orcid":false,"given":"Ting","family":"Cheng","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Brain Disease Research Institute, Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0250-1314","authenticated-orcid":false,"given":"Hu","family":"Xi","sequence":"additional","affiliation":[{"name":"Anhui University of Chinese Medicine, Hefei 230038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-8481","authenticated-orcid":false,"given":"Wenjie","family":"Hao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Brain Disease Research Institute, Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-5438","authenticated-orcid":false,"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Brain Disease Research Institute, Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1958-0348","authenticated-orcid":false,"given":"Nannan","family":"Qian","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Brain Disease Research Institute, Anhui University of Chinese Medicine, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-9291","authenticated-orcid":false,"given":"Wenming","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Brain Disease Research Institute, Anhui University of Chinese Medicine, Hefei 230031, China"},{"name":"Key Laboratory of XinAn Medicine, Ministry of Education, Hefei 230038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"219","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"S0192415X26500540BIB001","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030281"},{"key":"S0192415X26500540BIB002","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103211"},{"key":"S0192415X26500540BIB003","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0"},{"key":"S0192415X26500540BIB004","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03199-0"},{"key":"S0192415X26500540BIB005","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S247406"},{"key":"S0192415X26500540BIB006","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"S0192415X26500540BIB007","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239"},{"key":"S0192415X26500540BIB008","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092591"},{"key":"S0192415X26500540BIB009","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121525"},{"key":"S0192415X26500540BIB010","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1604071"},{"key":"S0192415X26500540BIB011","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8498"},{"key":"S0192415X26500540BIB012","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.04.073"},{"key":"S0192415X26500540BIB013","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117081"},{"key":"S0192415X26500540BIB014","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA02170G"},{"key":"S0192415X26500540BIB015","doi-asserted-by":"publisher","DOI":"10.1038\/nature14344"},{"key":"S0192415X26500540BIB016","doi-asserted-by":"publisher","DOI":"10.3389\/ebm.2024.10280"},{"key":"S0192415X26500540BIB017","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8"},{"key":"S0192415X26500540BIB018","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.724525"},{"key":"S0192415X26500540BIB019","doi-asserted-by":"publisher","DOI":"10.3390\/cells13030287"},{"key":"S0192415X26500540BIB020","doi-asserted-by":"publisher","DOI":"10.3390\/polym13213833"},{"key":"S0192415X26500540BIB021","doi-asserted-by":"publisher","DOI":"10.3390\/ma14195759"},{"key":"S0192415X26500540BIB022","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.910292"},{"key":"S0192415X26500540BIB023","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154962"},{"key":"S0192415X26500540BIB024","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S206044"},{"key":"S0192415X26500540BIB025","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116832"},{"key":"S0192415X26500540BIB026","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113227"},{"key":"S0192415X26500540BIB027","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01350-1"},{"key":"S0192415X26500540BIB028","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2025.06.008"},{"key":"S0192415X26500540BIB029","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00876F"},{"key":"S0192415X26500540BIB030","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119990"},{"key":"S0192415X26500540BIB031","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"S0192415X26500540BIB032","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1368950"},{"key":"S0192415X26500540BIB033","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114550"},{"key":"S0192415X26500540BIB034","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.10.025"},{"key":"S0192415X26500540BIB035","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1"},{"key":"S0192415X26500540BIB036","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12101883"},{"key":"S0192415X26500540BIB037","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1552"},{"key":"S0192415X26500540BIB038","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1455534"},{"key":"S0192415X26500540BIB039","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155258"},{"key":"S0192415X26500540BIB040","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-024-3666-z"},{"key":"S0192415X26500540BIB041","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18016"},{"key":"S0192415X26500540BIB042","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175782"},{"key":"S0192415X26500540BIB043","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12866"},{"key":"S0192415X26500540BIB044","doi-asserted-by":"publisher","DOI":"10.3390\/md12115677"},{"key":"S0192415X26500540BIB045","doi-asserted-by":"publisher","DOI":"10.7150\/jca.90574"},{"key":"S0192415X26500540BIB046","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S51262"},{"key":"S0192415X26500540BIB047","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00768-7"},{"key":"S0192415X26500540BIB048","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S144615"},{"key":"S0192415X26500540BIB049","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-03537-z"},{"key":"S0192415X26500540BIB050","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24491"},{"key":"S0192415X26500540BIB051","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.644387"},{"key":"S0192415X26500540BIB052","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf374"},{"key":"S0192415X26500540BIB053","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-024-03812-4"},{"key":"S0192415X26500540BIB054","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157030"}],"container-title":["The American Journal of Chinese Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0192415X26500540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:10:07Z","timestamp":1784603407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/10.1142\/S0192415X26500540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"journal-issue":{"issue":"05","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1142\/S0192415X26500540"],"URL":"https:\/\/doi.org\/10.1142\/s0192415x26500540","relation":{},"ISSN":["0192-415X","1793-6853"],"issn-type":[{"value":"0192-415X","type":"print"},{"value":"1793-6853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}